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Apolipoprotein E genotype has no effect on the free intracellular Ca2+ concentration of platelets from Alzheimer's disease patients.

  • Authors:
    • M A Fernandes
    • M T Proença
    • A J Nogueira
    • L M Oliveira
    • B Santiago
    • I Santana
    • C R Oliveira

  • View Affiliations

  • Published online on: April 1, 1999     https://doi.org/10.3892/ijmm.3.4.431
  • Pages: 431-435
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Abstract

The free intracellular Ca2+ concentration [Ca2+]i of platelets was investigated in Alzheimer's disease (AD) patients and age-matched control subjects with distinct Apo E genotypes. No significant differences were found between the Apo E genotype and the [Ca2+]i levels of platelets (basal and alpha-thrombin stimulated) from AD patients and age-matched control subjects, suggesting that [Ca2+]i homeostasis of platelets from AD patients is independent of the Apo E genotype. The results are discussed in terms of involvement of Apo E and [Ca2+]i changes in the etiopathogenesis of AD.

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Journal Cover

Apr 1999
Volume 3 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Fernandes M, Proença M, Nogueira A, Oliveira L, Santiago B, Santana I and Oliveira C: Apolipoprotein E genotype has no effect on the free intracellular Ca2+ concentration of platelets from Alzheimer's disease patients.. Int J Mol Med 3: 431-435, 1999.
APA
Fernandes, M., Proença, M., Nogueira, A., Oliveira, L., Santiago, B., Santana, I., & Oliveira, C. (1999). Apolipoprotein E genotype has no effect on the free intracellular Ca2+ concentration of platelets from Alzheimer's disease patients.. International Journal of Molecular Medicine, 3, 431-435. https://doi.org/10.3892/ijmm.3.4.431
MLA
Fernandes, M., Proença, M., Nogueira, A., Oliveira, L., Santiago, B., Santana, I., Oliveira, C."Apolipoprotein E genotype has no effect on the free intracellular Ca2+ concentration of platelets from Alzheimer's disease patients.". International Journal of Molecular Medicine 3.4 (1999): 431-435.
Chicago
Fernandes, M., Proença, M., Nogueira, A., Oliveira, L., Santiago, B., Santana, I., Oliveira, C."Apolipoprotein E genotype has no effect on the free intracellular Ca2+ concentration of platelets from Alzheimer's disease patients.". International Journal of Molecular Medicine 3, no. 4 (1999): 431-435. https://doi.org/10.3892/ijmm.3.4.431