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Protein kinase C regulates NO-cGMP pathway in muscarinic receptor activation by HIV+-IgA.

  • Authors:
    • M E Sales
    • A J Español
    • L Sterin-Borda
    • E Borda
    • M M de Bracco

  • View Affiliations

  • Published online on: June 1, 1999     https://doi.org/10.3892/ijmm.3.6.633
  • Pages: 633-640
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

In this work we demostrate that IgA purified from HIV infected patients recognizes a band with a molecular weight corresponding to radiolabelled ileal muscarinic acethylcholine receptors (mAChR) by immunoblotting. HIV+-IgA triggers the signals that are the consequence of mAChR stimulation in the intestine, regulating protein kinase C (PKC) and nitric oxide synthase (NOS) activity as well as 3',5'-cyclic guanosine monophosphate (cGMP) formation. On the one hand PKC activation by HIV+-IgA induces NOS inhibition and as a consequence, low amounts of NO that could improve local immunosuppression in the intestine; on the other hand HIV+-IgA stimulates cGMP production which could potentiate ileal motility and loss of water/electrolytes involved in intestinal damage in AIDS.

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Journal Cover

Jun 1999
Volume 3 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Sales M, Español A, Sterin-Borda L, Borda E and de Bracco M: Protein kinase C regulates NO-cGMP pathway in muscarinic receptor activation by HIV+-IgA.. Int J Mol Med 3: 633-640, 1999.
APA
Sales, M., Español, A., Sterin-Borda, L., Borda, E., & de Bracco, M. (1999). Protein kinase C regulates NO-cGMP pathway in muscarinic receptor activation by HIV+-IgA.. International Journal of Molecular Medicine, 3, 633-640. https://doi.org/10.3892/ijmm.3.6.633
MLA
Sales, M., Español, A., Sterin-Borda, L., Borda, E., de Bracco, M."Protein kinase C regulates NO-cGMP pathway in muscarinic receptor activation by HIV+-IgA.". International Journal of Molecular Medicine 3.6 (1999): 633-640.
Chicago
Sales, M., Español, A., Sterin-Borda, L., Borda, E., de Bracco, M."Protein kinase C regulates NO-cGMP pathway in muscarinic receptor activation by HIV+-IgA.". International Journal of Molecular Medicine 3, no. 6 (1999): 633-640. https://doi.org/10.3892/ijmm.3.6.633