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Present and potential future use of gene therapy for the treatment of non-insulin dependent diabetes mellitus (Review).

  • Authors:
    • D J Freeman
    • I Leclerc
    • G A Rutter

  • View Affiliations

  • Published online on: December 1, 1999     https://doi.org/10.3892/ijmm.4.6.585
  • Pages: 585-677
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

This review describes the latest approaches towards using gene therapy as a treatment for non-insulin dependent diabetes mellitus (NIDDM; Type 2 diabetes). We examine attempts to directly deliver the insulin gene to non-beta-cells, to improve insulin secretion from existing beta-cells and to develop ex vivo approaches to implanting genetically modified cells. Future research into the pathology of non-insulin dependent diabetes, combined with the latest developments in gene delivery systems, may potentially make gene therapy an attractive alternative NIDDM treatment in the future.

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Dec 1999
Volume 4 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Freeman D, Leclerc I and Rutter G: Present and potential future use of gene therapy for the treatment of non-insulin dependent diabetes mellitus (Review).. Int J Mol Med 4: 585-677, 1999.
APA
Freeman, D., Leclerc, I., & Rutter, G. (1999). Present and potential future use of gene therapy for the treatment of non-insulin dependent diabetes mellitus (Review).. International Journal of Molecular Medicine, 4, 585-677. https://doi.org/10.3892/ijmm.4.6.585
MLA
Freeman, D., Leclerc, I., Rutter, G."Present and potential future use of gene therapy for the treatment of non-insulin dependent diabetes mellitus (Review).". International Journal of Molecular Medicine 4.6 (1999): 585-677.
Chicago
Freeman, D., Leclerc, I., Rutter, G."Present and potential future use of gene therapy for the treatment of non-insulin dependent diabetes mellitus (Review).". International Journal of Molecular Medicine 4, no. 6 (1999): 585-677. https://doi.org/10.3892/ijmm.4.6.585