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BHRF1 antisense oligonucleotide inhibits anti-apoptosis of nasopharyngeal carcinoma cells.

  • Authors:
    • H Huang
    • X Pan
    • J Zhou

  • View Affiliations

  • Published online on: December 1, 1999     https://doi.org/10.3892/ijmm.4.6.649
  • Pages: 649-702
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Epstein-Barr virus gene BHRF1 has homology with proto-oncogene bcl-2, which can protect cells from apoptosis, thus, it may play important roles in oncogenesis and affect treatment of EBV-related cancers. We used BHRF1 antisense oligonucleotide to block its expression in nasopharyngeal carcinoma cell line, CNE2. The results showed that after blocking by BHRF1 antisense oligonucleotide, CNE2 cells had higher S-phase cell percentage, more susceptibility to radiation with weaker ability of proliferation, colony forming efficiency and tumor development in nude mice after radiation. Our results suggest that BHRF1 antisense oligonucleotide could inhibit BHRF1 anti-apoptotic ability, and may contribute to the treatment of EBV-related cancers.

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Journal Cover

Dec 1999
Volume 4 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Huang H, Pan X and Zhou J: BHRF1 antisense oligonucleotide inhibits anti-apoptosis of nasopharyngeal carcinoma cells.. Int J Mol Med 4: 649-702, 1999.
APA
Huang, H., Pan, X., & Zhou, J. (1999). BHRF1 antisense oligonucleotide inhibits anti-apoptosis of nasopharyngeal carcinoma cells.. International Journal of Molecular Medicine, 4, 649-702. https://doi.org/10.3892/ijmm.4.6.649
MLA
Huang, H., Pan, X., Zhou, J."BHRF1 antisense oligonucleotide inhibits anti-apoptosis of nasopharyngeal carcinoma cells.". International Journal of Molecular Medicine 4.6 (1999): 649-702.
Chicago
Huang, H., Pan, X., Zhou, J."BHRF1 antisense oligonucleotide inhibits anti-apoptosis of nasopharyngeal carcinoma cells.". International Journal of Molecular Medicine 4, no. 6 (1999): 649-702. https://doi.org/10.3892/ijmm.4.6.649