Estrogen receptor variants are present in many normal human tissues.
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- Published online on: March 1, 2000 https://doi.org/10.3892/ijmm.5.3.223
- Pages: 223-230
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Abstract
Estrogen receptors (ER) are present in various reproductive tissues as well as in other tissues not considered classical targets for estrogen. A variety of alternatively spliced ER variants which co-exist with the wild-type receptor has also been described in many tissues. We analyzed the presence of both wild-type and variant receptors from normal human tissues of various origin using semi-nested PCR and direct automated sequence of the amplified products. We demonstrate that many normal human tissues of various origin contain a number of spliced variants of the estrogen receptor that co-exist with the wild-type receptor. Variants lacking exons 2, 4, 5, and 7 are detected in a variety of normal human tissues.