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Leptin expression in colorectal and breast cancer patients.

  • Authors:
    • L Tessitore
    • B Vizio
    • O Jenkins
    • I De Stefano
    • C Ritossa
    • J M Argiles
    • C Benedetto
    • A Mussa

  • View Affiliations

  • Published online on: April 1, 2000     https://doi.org/10.3892/ijmm.5.4.421
  • Pages: 421-427
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Leptin is a hormone which controls fat metabolism. Leptin plasma levels and adipose tissue mRNA expression were measured in cancer patients. Plasma levels were correlated with TNM staging, cachexia parameters, tumour markers and hormones. Breast and colorectal cancer patients showed blood plasma levels of insulin, TNF-alpha and tumour markers higher than controls. Breast cancer patients, but not colorectal cancer patients, had plasma levels and adipose tissue expression of leptin significantly higher than controls associated with elevated values of estrogen- and progesterone-receptors. These data suggest the possible use of leptin as a clinical marker.

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Journal Cover

Apr 2000
Volume 5 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Tessitore L, Vizio B, Jenkins O, De Stefano I, Ritossa C, Argiles J, Benedetto C and Mussa A: Leptin expression in colorectal and breast cancer patients.. Int J Mol Med 5: 421-427, 2000.
APA
Tessitore, L., Vizio, B., Jenkins, O., De Stefano, I., Ritossa, C., Argiles, J. ... Mussa, A. (2000). Leptin expression in colorectal and breast cancer patients.. International Journal of Molecular Medicine, 5, 421-427. https://doi.org/10.3892/ijmm.5.4.421
MLA
Tessitore, L., Vizio, B., Jenkins, O., De Stefano, I., Ritossa, C., Argiles, J., Benedetto, C., Mussa, A."Leptin expression in colorectal and breast cancer patients.". International Journal of Molecular Medicine 5.4 (2000): 421-427.
Chicago
Tessitore, L., Vizio, B., Jenkins, O., De Stefano, I., Ritossa, C., Argiles, J., Benedetto, C., Mussa, A."Leptin expression in colorectal and breast cancer patients.". International Journal of Molecular Medicine 5, no. 4 (2000): 421-427. https://doi.org/10.3892/ijmm.5.4.421