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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Dec 2000 Volume 6 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Dec 2000 Volume 6 Issue 6

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Article

D-mannoheptulose uptake and its metabolic and secretory effects in human pancreatic islets.

  • Authors:
    • A Sener
    • L Ladriere
    • C Benito
    • R Gomis
    • F Malaisse-Lagae
    • W J Malaisse
  • View Affiliations / Copyright

    Affiliations: Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium.
  • Pages: 617-637
    |
    Published online on: December 1, 2000
       https://doi.org/10.3892/ijmm.6.6.617
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Abstract

D-mannoheptulose was recently proposed to be transported into cells at the intervention of GLUT2. Since GLUT1, rather than GLUT2, represents the major carrier system for the transport of monosaccharides across the islet B-cell plasma membrane in human subjects, the uptake of D-mannoheptulose and its metabolic and secretory effects were investigated in human islets. The uptake of D-glucose reached much more rapidly a close-to-equilibrium value in isolated islets than in pieces of pancreas obtained from the same donor. The distribution space of D-[3H]mannoheptulose in the human islets largely exceeded that of [U-14C]sucrose, considered as an extracellular marker, and did not differ significantly from that of 3HOH. In the human islets, the heptose (10.0 mM) inhibited both D-[5-3H]glucose utilization and D-[U-14C] glucose oxidation, and decreased glucose-stimulated insulin release to the same extent as D-mannoheptulose hexaacetate. These findings indicate that a suitable radioactive analog of D-mannoheptulose could be used, in human like in rat islets, for preferential labelling of the endocrine moiety of the pancreatic gland.

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Copy and paste a formatted citation
Spandidos Publications style
Sener A, Ladriere L, Benito C, Gomis R, Malaisse-Lagae F and Malaisse W: D-mannoheptulose uptake and its metabolic and secretory effects in human pancreatic islets.. Int J Mol Med 6: 617-637, 2000.
APA
Sener, A., Ladriere, L., Benito, C., Gomis, R., Malaisse-Lagae, F., & Malaisse, W. (2000). D-mannoheptulose uptake and its metabolic and secretory effects in human pancreatic islets.. International Journal of Molecular Medicine, 6, 617-637. https://doi.org/10.3892/ijmm.6.6.617
MLA
Sener, A., Ladriere, L., Benito, C., Gomis, R., Malaisse-Lagae, F., Malaisse, W."D-mannoheptulose uptake and its metabolic and secretory effects in human pancreatic islets.". International Journal of Molecular Medicine 6.6 (2000): 617-637.
Chicago
Sener, A., Ladriere, L., Benito, C., Gomis, R., Malaisse-Lagae, F., Malaisse, W."D-mannoheptulose uptake and its metabolic and secretory effects in human pancreatic islets.". International Journal of Molecular Medicine 6, no. 6 (2000): 617-637. https://doi.org/10.3892/ijmm.6.6.617
Copy and paste a formatted citation
x
Spandidos Publications style
Sener A, Ladriere L, Benito C, Gomis R, Malaisse-Lagae F and Malaisse W: D-mannoheptulose uptake and its metabolic and secretory effects in human pancreatic islets.. Int J Mol Med 6: 617-637, 2000.
APA
Sener, A., Ladriere, L., Benito, C., Gomis, R., Malaisse-Lagae, F., & Malaisse, W. (2000). D-mannoheptulose uptake and its metabolic and secretory effects in human pancreatic islets.. International Journal of Molecular Medicine, 6, 617-637. https://doi.org/10.3892/ijmm.6.6.617
MLA
Sener, A., Ladriere, L., Benito, C., Gomis, R., Malaisse-Lagae, F., Malaisse, W."D-mannoheptulose uptake and its metabolic and secretory effects in human pancreatic islets.". International Journal of Molecular Medicine 6.6 (2000): 617-637.
Chicago
Sener, A., Ladriere, L., Benito, C., Gomis, R., Malaisse-Lagae, F., Malaisse, W."D-mannoheptulose uptake and its metabolic and secretory effects in human pancreatic islets.". International Journal of Molecular Medicine 6, no. 6 (2000): 617-637. https://doi.org/10.3892/ijmm.6.6.617
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