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Is ApoE gene a risk factor for vascular dementia in Han Chinese?

  • Authors:
    • Jiandong Yang
    • Guoyin Feng
    • Jing Zhang
    • Zhu Hui
    • Gerome Breen
    • David St Clair
    • Lin He

  • View Affiliations

  • Published online on: February 1, 2001     https://doi.org/10.3892/ijmm.7.2.217
  • Pages: 217-219
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

We have compared the apolipoprotein E (ApoE) genotypes of Han Chinese with late-onset sporadic Alzheimer's disease (LOAD, n=191), and vascular dementia (VaD, n=124) to controls (n=218) with a similar age distribution. The frequency of ApoE ε4 allele in the LOAD group was significantly higher than that in the control group (30.1% versus 10.55%, p<10-7). The risk rate of LOAD was 3.5 times higher for carriers with at least one ApoE ε4 allele than for non-ε4 bearing controls. ApoE ε4 allele was also significantly associated with vascular dementia (OR=1.75, p=0.026). Our findings support previous reports of a positive association between ApoE ε4 and both Alzheimer's disease and vascular dementia in Han Chinese.

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Journal Cover

February 2001
Volume 7 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Yang J, Feng G, Zhang J, Hui Z, Breen G, St Clair D and He L: Is ApoE gene a risk factor for vascular dementia in Han Chinese?. Int J Mol Med 7: 217-219, 2001.
APA
Yang, J., Feng, G., Zhang, J., Hui, Z., Breen, G., St Clair, D., & He, L. (2001). Is ApoE gene a risk factor for vascular dementia in Han Chinese?. International Journal of Molecular Medicine, 7, 217-219. https://doi.org/10.3892/ijmm.7.2.217
MLA
Yang, J., Feng, G., Zhang, J., Hui, Z., Breen, G., St Clair, D., He, L."Is ApoE gene a risk factor for vascular dementia in Han Chinese?". International Journal of Molecular Medicine 7.2 (2001): 217-219.
Chicago
Yang, J., Feng, G., Zhang, J., Hui, Z., Breen, G., St Clair, D., He, L."Is ApoE gene a risk factor for vascular dementia in Han Chinese?". International Journal of Molecular Medicine 7, no. 2 (2001): 217-219. https://doi.org/10.3892/ijmm.7.2.217