Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats
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- Published online on: November 1, 2001 https://doi.org/10.3892/ijmm.8.5.531
- Pages: 531-532
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Abstract
The dimethyl ester of L-glutamic acid (DMG) stimulates insulin release and was proposed as a possible insulinotropic tool in the treatment of non-insulin-dependent diabetes. In such a perspective, it was investigated whether DMG enhances the B-cell secretory response to GLP-1 in fed anaesthetized rats. The primed constant infusion of DMG (1.0 μmol and then 0.5 μmol/min, both per g body wt.) provoked a rapid and sustained increase in plasma insulin concentration and augmented the release of insulin caused by GLP-1. Thus, DMG indeed appears as a suitable tool to potentiate the insulinotropic action of GLP-1.
