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Altered expression of low affinity insulin-like growth factor binding protein related proteins in hepatoblastoma

  • Authors:
    • Henrik Von Horn
    • Vivian Hwa
    • Ron G. Rosenfeld
    • Kerstin Hall
    • Bin Tean Teh
    • Michael Tally
    • Tomas J. Ekstrom
    • Steven G. Gray

  • View Affiliations

  • Published online on: June 1, 2002     https://doi.org/10.3892/ijmm.9.6.645
  • Pages: 645-649
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Hepatoblastoma is a poorly understood rare pediatric liver tumour. We have previously shown that the IGF-axis is seriously disrupted in this tumour type. With the recent discovery that several other proteins also have the potential to bind to IGFs called insulin-like growth factor binding protein related proteins (IGFBP-rPs), we undertook an examination of several such genes in a series of hepatoblastomas with matched normal liver tissue. The expression profiles obtained reveal that the expression of these genes are also disturbed in these tumours, and may have implications for our understanding of the IGF-axis and its importance in this disease.

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Journal Cover

June 2002
Volume 9 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Von Horn H, Hwa V, Rosenfeld RG, Hall K, Teh BT, Tally M, Ekstrom TJ and Gray SG: Altered expression of low affinity insulin-like growth factor binding protein related proteins in hepatoblastoma. Int J Mol Med 9: 645-649, 2002.
APA
Von Horn, H., Hwa, V., Rosenfeld, R.G., Hall, K., Teh, B.T., Tally, M. ... Gray, S.G. (2002). Altered expression of low affinity insulin-like growth factor binding protein related proteins in hepatoblastoma. International Journal of Molecular Medicine, 9, 645-649. https://doi.org/10.3892/ijmm.9.6.645
MLA
Von Horn, H., Hwa, V., Rosenfeld, R. G., Hall, K., Teh, B. T., Tally, M., Ekstrom, T. J., Gray, S. G."Altered expression of low affinity insulin-like growth factor binding protein related proteins in hepatoblastoma". International Journal of Molecular Medicine 9.6 (2002): 645-649.
Chicago
Von Horn, H., Hwa, V., Rosenfeld, R. G., Hall, K., Teh, B. T., Tally, M., Ekstrom, T. J., Gray, S. G."Altered expression of low affinity insulin-like growth factor binding protein related proteins in hepatoblastoma". International Journal of Molecular Medicine 9, no. 6 (2002): 645-649. https://doi.org/10.3892/ijmm.9.6.645