Classification of hypocholesterolemia lipid patterns using Chol/Trig Combination System

  • Authors:
    • Kinue Ooi
    • Kazushi Sugimoto
    • Katsuya Shiraki
    • Norihiko Yamamoto
    • Masahiko Tameda
    • Tetsuya Beppu
    • Junichiro Tanaka
    • Keiichiro Nojiri
    • Satoko Kusagawa
    • Yoshiyuki Takei
    • Chiaki Masuda
    • Tsutomu Nobori
  • View Affiliations

  • Published online on: April 1, 2010     https://doi.org/10.3892/ijmm_00000382
  • Pages: 601-606
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Abstract

Patterns of hypocholesterolemic lipid fractions in 295 patients with liver diseases, malignant tumors, arteriosclerotic and renal diseases with cholesterol (Chol) levels of <30 mg/dl were classified using a simultaneous analytical method for the Chol and triglyceride (TG) fractions (Chol/Trig Combo System). Hypocholesterolemia was classified as follows: IV, Type IV on WHO hyperlipidemia phenotype classification; intermediate density lipoprotein (IDL), cases with appearance of IDL, including appearance of Lp(a); high + low density lipoproteins (HDL+LDL), lipids mostly consisting of HDL and LDL fractions; HDL abnormality, cases with slow αHDL or fast HDL; abnormal LDL, both Chol and TG fractions mostly consisting of LDL fraction; normal type, ratios of HDL, very low density lipoproteins (VLD) and LDL fractions were almost normal; and low HDL, HDL-C was <30 mg/dl. Many patients with liver diseases had HDL+LDL (45%), and abnormal LDL was noted in 13% of the cases. In malignant tumors, the frequencies of low HDL, normal type, and HDL+LDL cases were similar (22-30%). In arteriosclerosis, normal type accounted for 46% of the cases, and the frequency of normal type was higher (60%) in renal diseases. Mortality rate (within 1 year after measurement) was then compared among lipid patterns. In liver diseases, mortality rate increased in the following order: abnormal LDL (55%); low HDL (31%); HDL abnormality (25%); and HDL+LDL (21%). No deaths were seen among patients with normal type. In malignant tumors, mortality rate was very high (88%) in patients with HDL+LDL, but low in patients with normal type (22%) and low HDL (9%). Mortality rate was low in patients with arteriosclerosis and renal diseases in the short-term follow-up period (1 year). In the comparisons of distribution, mean, and appearance rate of charge modification frequency (CMF) among lipid patterns, parameters were high in all patterns other than HDL+LDL. Classification of hypocholesterolemia lipid patterns and evaluation of CMF may therefore be clinically useful.

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April 2010
Volume 25 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Ooi K, Sugimoto K, Shiraki K, Yamamoto N, Tameda M, Beppu T, Tanaka J, Nojiri K, Kusagawa S, Takei Y, Takei Y, et al: Classification of hypocholesterolemia lipid patterns using Chol/Trig Combination System. Int J Mol Med 25: 601-606, 2010.
APA
Ooi, K., Sugimoto, K., Shiraki, K., Yamamoto, N., Tameda, M., Beppu, T. ... Nobori, T. (2010). Classification of hypocholesterolemia lipid patterns using Chol/Trig Combination System. International Journal of Molecular Medicine, 25, 601-606. https://doi.org/10.3892/ijmm_00000382
MLA
Ooi, K., Sugimoto, K., Shiraki, K., Yamamoto, N., Tameda, M., Beppu, T., Tanaka, J., Nojiri, K., Kusagawa, S., Takei, Y., Masuda, C., Nobori, T."Classification of hypocholesterolemia lipid patterns using Chol/Trig Combination System". International Journal of Molecular Medicine 25.4 (2010): 601-606.
Chicago
Ooi, K., Sugimoto, K., Shiraki, K., Yamamoto, N., Tameda, M., Beppu, T., Tanaka, J., Nojiri, K., Kusagawa, S., Takei, Y., Masuda, C., Nobori, T."Classification of hypocholesterolemia lipid patterns using Chol/Trig Combination System". International Journal of Molecular Medicine 25, no. 4 (2010): 601-606. https://doi.org/10.3892/ijmm_00000382