METHODOLOGICAL ASPECTS OF PHASE-I STUDIES OF NOVEL ANTICANCER AGENTS (REVIEW)
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- Published online on: July 1, 1992 https://doi.org/10.3892/ijo.1.2.195
- Pages: 195-199
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Abstract
In the last 5 years we have performed 14 phase I studies in our department. Eight of these trials involved evaluation of both the clinical and the pharmacokinetic behaviour of novel anti-cancer agents. The remainder investigated various aspects of drug delivery, targetting or resistance modification with existing anti-cancer drugs. In total these studies have involved over 200 patients. In this review article we have drawn upon our experience to suggest guidelines for future studies.