HUMAN AND RODENT FIBROBLASTS - MODEL SYSTEMS FOR STUDYING SENESCENCE AND IMMORTALIZATION (REVIEW)
- Authors:
- Published online on: July 1, 1992 https://doi.org/10.3892/ijo.1.2.209
- Pages: 209-213
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Abstract
Normal mammalian fibroblasts cultured in vitro will not divide indefinitely but undergo senescence and give rise to cells that can no longer be induced to divide. It is possible to overcome this finite life span by either cellular mutation or by the exogenous introduction of some viral or cellular oncogenes. This review describes the characteristics of senescence and the different ways in which it can be overcome.