A CIRCULATING HEAT-RESISTANT MUCIN-LIKE ANTIGEN IN PATIENTS WITH LUNG-CANCER DETECTED BY A NEW MURINE MONOCLONAL-ANTIBODY
- Authors:
- Published online on: November 1, 1992 https://doi.org/10.3892/ijo.1.6.649
- Pages: 649-655
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Abstract
We discovered a circulating mucin-like antigen designated as CAM-14 detected by a new murine monoclonal antibody KL-14 (IgM). We found different heat resistant properties between serum CAM- 14 from normal individuals and from lung cancer patients. Heat treatment had less effect on the levels of CAM-14 in sera from lung cancer patients, whereas CAM-14 levels in sera from normal individuals were markedly decreased after heat treatment at tempratures > 65-degrees-C. As a serum tumor marker, CAM- 14 had only very low levels of false-positive values with a high specificity and effectively increased the positive rate for lung cancer patients when used together with carcinoembryonic antigen.
