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INCREASED RESISTANCE TO DOXORUBICIN IN HUMAN NON-SMALL-CELL LUNG CARCINOMAS WITH METALLOTHIONEIN EXPRESSION

  • Authors:
    • J MATTERN
    • M VOLM

  • View Affiliations

  • Published online on: November 1, 1992     https://doi.org/10.3892/ijo.1.6.687
  • Pages: 687-689
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Abstract

Ninety-four human non-small cell lung carcinomas (NSCLC) of previously untreated patients were analyzed for the presence of metallothionein (MT) expression by means of immunohistochemistry. Of the tumors investigated, expression of MT was detected in 63%. The expression of MT was correlated with the results of doxorubicin resistance of the tumors in vitro. A significant relationship between MT expression and doxorubicin resistance was found (p=0.01). Significant correlations also exist between MT and P-glycoprotein or glutathione-S-transferase-pi expression respectively (p<0.005).

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November 1992
Volume 1 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 4.5
  • Ranked Oncology
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
MATTERN J and VOLM M: INCREASED RESISTANCE TO DOXORUBICIN IN HUMAN NON-SMALL-CELL LUNG CARCINOMAS WITH METALLOTHIONEIN EXPRESSION. Int J Oncol 1: 687-689, 1992.
APA
MATTERN, J., & VOLM, M. (1992). INCREASED RESISTANCE TO DOXORUBICIN IN HUMAN NON-SMALL-CELL LUNG CARCINOMAS WITH METALLOTHIONEIN EXPRESSION. International Journal of Oncology, 1, 687-689. https://doi.org/10.3892/ijo.1.6.687
MLA
MATTERN, J., VOLM, M."INCREASED RESISTANCE TO DOXORUBICIN IN HUMAN NON-SMALL-CELL LUNG CARCINOMAS WITH METALLOTHIONEIN EXPRESSION". International Journal of Oncology 1.6 (1992): 687-689.
Chicago
MATTERN, J., VOLM, M."INCREASED RESISTANCE TO DOXORUBICIN IN HUMAN NON-SMALL-CELL LUNG CARCINOMAS WITH METALLOTHIONEIN EXPRESSION". International Journal of Oncology 1, no. 6 (1992): 687-689. https://doi.org/10.3892/ijo.1.6.687