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The peripheral myelin protein 22 kDa (PMP22) gene is amplified in cell lines derived from glioma and osteogenic sarcoma

  • Authors:
    • T Liehr
    • O Park
    • B Feuerstein
    • E Gebhart
    • B Rautenstrauss

  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/ijo.10.5.915
  • Pages: 915-919
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Abstract

Two glioma (SF188, SF763) and two osteogenic sarcoma cell lines (RH30, SA1) were examined for the presence of an amplification of the PMP22 gene by means of fluorescence in situ hybridization (FISH). In one cell line of both cell types, we found about 10 copies of the PMP22 (peripheral myelin protein 22 kDa) gene, located on different marker chromosomes within homogeneously staining regions. Surrounding chromosome 17p material was found to be coamplified, but coamplification of TP53 (17p13) and erbB2/Her2 (17q11.12) were excluded by FISH for both cell lines, SF763 and RH30. This is the first report of a PMP22 amplification in cell lines derived from human tumors.

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May 1997
Volume 10 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 4.5
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Liehr T, Park O, Feuerstein B, Gebhart E and Rautenstrauss B: The peripheral myelin protein 22 kDa (PMP22) gene is amplified in cell lines derived from glioma and osteogenic sarcoma. Int J Oncol 10: 915-919, 1997.
APA
Liehr, T., Park, O., Feuerstein, B., Gebhart, E., & Rautenstrauss, B. (1997). The peripheral myelin protein 22 kDa (PMP22) gene is amplified in cell lines derived from glioma and osteogenic sarcoma. International Journal of Oncology, 10, 915-919. https://doi.org/10.3892/ijo.10.5.915
MLA
Liehr, T., Park, O., Feuerstein, B., Gebhart, E., Rautenstrauss, B."The peripheral myelin protein 22 kDa (PMP22) gene is amplified in cell lines derived from glioma and osteogenic sarcoma". International Journal of Oncology 10.5 (1997): 915-919.
Chicago
Liehr, T., Park, O., Feuerstein, B., Gebhart, E., Rautenstrauss, B."The peripheral myelin protein 22 kDa (PMP22) gene is amplified in cell lines derived from glioma and osteogenic sarcoma". International Journal of Oncology 10, no. 5 (1997): 915-919. https://doi.org/10.3892/ijo.10.5.915