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In vitro and in vivo MRS study of human glioma metabolites

  • Authors:
    • V Tugnoli
    • M Tosi
    • G Barbarella
    • R Ricci
    • F Calbucci
    • A Bertoluzza

  • View Affiliations

  • Published online on: August 1, 1997     https://doi.org/10.3892/ijo.11.2.319
  • Pages: 319-324
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Abstract

In this study an in vitro multinuclear magnetic resonance spectroscopy (MRS) characterization of water soluble metabolites and of the lipid fraction obtained from 19 human gliomas (12 glioblastomas, 3 anaplastic astrocytomas, 2 anaplastic oligodendrogliomas and 2 oligodendrogliomas) with a total of 27 surgical specimens, is reported. Moreover, some in vivo H-1 MRS results are shown. The regional metabolic heterogeneity of glioblastomas, according to their morphological heterogeneity, is documented. For glioblastomas a specific in vitro H-1 MRS metabolite profile cannot be defined. Low and high grade oligodendrogliomas showed characteristic choline/creatine and alanine/creatine metabolite ratios. The spectroscopical characterization of histopathological factors concerning malignant gliomas is shown.

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August 1997
Volume 11 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Tugnoli V, Tosi M, Barbarella G, Ricci R, Calbucci F and Bertoluzza A: In vitro and in vivo MRS study of human glioma metabolites. Int J Oncol 11: 319-324, 1997.
APA
Tugnoli, V., Tosi, M., Barbarella, G., Ricci, R., Calbucci, F., & Bertoluzza, A. (1997). In vitro and in vivo MRS study of human glioma metabolites. International Journal of Oncology, 11, 319-324. https://doi.org/10.3892/ijo.11.2.319
MLA
Tugnoli, V., Tosi, M., Barbarella, G., Ricci, R., Calbucci, F., Bertoluzza, A."In vitro and in vivo MRS study of human glioma metabolites". International Journal of Oncology 11.2 (1997): 319-324.
Chicago
Tugnoli, V., Tosi, M., Barbarella, G., Ricci, R., Calbucci, F., Bertoluzza, A."In vitro and in vivo MRS study of human glioma metabolites". International Journal of Oncology 11, no. 2 (1997): 319-324. https://doi.org/10.3892/ijo.11.2.319