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Polymorphonuclear elastase in human colorectal carcinoma.

  • Authors:
    • K Bjørnland
    • L Buø
    • H Scott
    • Y Konttinen
    • H T Johansen
    • A O Aasen

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  • Published online on: March 1, 1998     https://doi.org/10.3892/ijo.12.3.535
  • Pages: 535-575
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Abstract

proteinases are required for invasion through the extracellular matrix (ECM) during tumor invasion and metastasis. Polymorphonuclear (PMN) elastase can degrade ECM components and modulate other proteinases. In the present study PMN elastase activity was found in tissue extracts from 8 of 15 human colorectal carcinomas. Immunoreactive PMN elastase was demonstrated in all carcinoma biopsies with particular enrichment at the tumor-host interface. Immunofluorescence staining localized immunoreactive PMN elastase mainly to neutrophile granulocytes. The human colon carcinoma cell lines Caco-2 and HT-29 did not express PMN elastase. An interaction between tumor cells and elastase producing leukocytes is suggested.

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Journal Cover

Mar 1998
Volume 12 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Bjørnland K, Buø L, Scott H, Konttinen Y, Johansen H and Aasen A: Polymorphonuclear elastase in human colorectal carcinoma.. Int J Oncol 12: 535-575, 1998.
APA
Bjørnland, K., Buø, L., Scott, H., Konttinen, Y., Johansen, H., & Aasen, A. (1998). Polymorphonuclear elastase in human colorectal carcinoma.. International Journal of Oncology, 12, 535-575. https://doi.org/10.3892/ijo.12.3.535
MLA
Bjørnland, K., Buø, L., Scott, H., Konttinen, Y., Johansen, H., Aasen, A."Polymorphonuclear elastase in human colorectal carcinoma.". International Journal of Oncology 12.3 (1998): 535-575.
Chicago
Bjørnland, K., Buø, L., Scott, H., Konttinen, Y., Johansen, H., Aasen, A."Polymorphonuclear elastase in human colorectal carcinoma.". International Journal of Oncology 12, no. 3 (1998): 535-575. https://doi.org/10.3892/ijo.12.3.535