Cell kinetic patterns in early gastric cancer.

Spina,D; Miracco,C; Vindigni,C; Gallorini,M; Presenti,L; Marrelli,D; Roviello,F; Pinto,E; Filipe,M I; Tosi,P

doi:10.3892/ijo.12.4.883

Cell kinetic patterns in early gastric cancer.

Authors:
- D Spina
- C Miracco
- C Vindigni
- M Gallorini
- L Presenti
- D Marrelli
- F Roviello
- E Pinto
- M I Filipe
- P Tosi
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Affiliations: Institute of Pathological Anatomy and Histology, University of Siena, Italy.
Published online on: April 1, 1998 https://doi.org/10.3892/ijo.12.4.883
Pages: 883-891

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Abstract

Early gastric cancers (EGC) may be subdivided into 2 groups by means of the use of mitotic index, apoptotic index and cell density: EGCs with high cell turnover and low cell density, which show high cell dissociation and, more frequently, lymph node invasion; EGCs with low cell turnover and high cell density. The same parameters discriminate among intestinal type tumors, when separately considered from diffuse ones. No correlation is noted of these 2 groups with transforming growth factor-alpha, epidermal growth factor receptor and p53 expression, gross type, entity of neoangiogenesis, and submucosal invasion.