Characterisation of a collecting duct carcinoma by cytogenetic analysis and comparative genomic hybridisation.

Verdorfer,I; Culig,Z; Hobisch,A; Bartsch,G; Hittmair,A; Duba,H C; Erdel,M

doi:10.3892/ijo.13.3.461

Characterisation of a collecting duct carcinoma by cytogenetic analysis and comparative genomic hybridisation.

Authors:
- I Verdorfer
- Z Culig
- A Hobisch
- G Bartsch
- A Hittmair
- H C Duba
- M Erdel
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Affiliations: Institut fur Medizinische Biologie und Humangenetik der Universitat Innsbruck, A-6020 Innsbruck, Austria.
Published online on: September 1, 1998 https://doi.org/10.3892/ijo.13.3.461
Pages: 461-465

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Abstract

Collecting duct carcinoma (CDC) is a rare variant of carcinoma of the kidney with aggressive behaviour. CDC arise from the epithelium of the ducts of Bellini in the distal nephron. A CDC in a 53-year old male patient is characterised both by cytogenetic analysis and comparative genomic hybridisation (CGH). The cytogenetic analysis shows a biclonal karyotype 47,XY,+3[2]/40-44,XY,-12[3], -22[4][cp5]/46,XY[42]. Loss of DNA sequences detected by CGH involves chromosome 1, 2, 9, 11 and 18. Gain of DNA sequences affect chromosome 16 and 20. The characterisation of a CDC in this study represents an additional contribution to the poorly explored CDC.