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Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer.

  • Authors:
    • J Edwards
    • J M Bartlett

  • View Affiliations

  • Published online on: September 1, 1999     https://doi.org/10.3892/ijo.15.3.583
  • Pages: 583-591
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Abstract

Inhibition of mitosis or induction of apoptosis are pathways at which anti tumour therapies could be aimed. This study evaluates the actions of CGP52411 (cell growth inhibitor) and transforming growth factor beta1 (TGFbeta1) (inducer of apoptosis) alone and in combination on two ovarian carcinoma cell lines (PEO1 and OVCAR3). In both cell lines TGFbeta1 treatment increased the level of apoptotic cells and CGP52411 treatment reduced EGF stimulated cell growth. Combined treatment further reduced cell numbers in PEO1 cultures, demonstrating that dual therapy aimed at both aspects of cell regulation has a greater anti tumour action.

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Journal Cover

Sep 1999
Volume 15 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Edwards J and Bartlett J: Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer.. Int J Oncol 15: 583-591, 1999.
APA
Edwards, J., & Bartlett, J. (1999). Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer.. International Journal of Oncology, 15, 583-591. https://doi.org/10.3892/ijo.15.3.583
MLA
Edwards, J., Bartlett, J."Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer.". International Journal of Oncology 15.3 (1999): 583-591.
Chicago
Edwards, J., Bartlett, J."Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer.". International Journal of Oncology 15, no. 3 (1999): 583-591. https://doi.org/10.3892/ijo.15.3.583