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In vitro antitumour activity and cellular pharmacological properties of the platinum-iminoether complex trans-[PtCl2[E-HN=C(OMe)Me]2].

  • Authors:
    • M Coluccia
    • A Nassi
    • A Boccarelli
    • D Giordano
    • N Cardellicchio
    • F P Intini
    • G Natile
    • A Barletta
    • A Paradiso

  • View Affiliations

  • Published online on: November 1, 1999     https://doi.org/10.3892/ijo.15.5.1039
  • Pages: 1039-1083
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Abstract

The platinum complex trans-[PtCl2¿E-HN=C(OMe)Me¿2] was compared to cisplatin for cytotoxicity towards tumour cells, and for cellular pharmacological properties in A2780 and cisplatin-resistant A2780/Cp8 ovarian cancer cells. Trans-[PtCl2¿E-HN=C(OMe)Me¿2] was comparably cytotoxic to cisplatin (mean IC50 after 72 h exposure = 6. 1 microM and 7 microM, respectively) and did not show cross-resistance in A2780/Cp8 cells (resistance factor = 0.9). Cellular accumulation measurements after treatment with equimolar drug concentrations showed that trans-[PtCl2¿E-HN=C(OMe)Me¿2] entered both A2780 and A2780/Cp8 cells much more efficiently than cisplatin, whose accumulation was reduced in A2780/Cp8 cells. Unlike cisplatin, trans-[PtCl2¿E-HN=C(OMe)Me¿2] induced rapidly cell death and cell cycle modifications of treated cells, thus indicating substantially different mechanistic properties.

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Nov 1999
Volume 15 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Coluccia M, Nassi A, Boccarelli A, Giordano D, Cardellicchio N, Intini F, Natile G, Barletta A and Paradiso A: In vitro antitumour activity and cellular pharmacological properties of the platinum-iminoether complex trans-[PtCl2[E-HN=C(OMe)Me]2].. Int J Oncol 15: 1039-1083, 1999.
APA
Coluccia, M., Nassi, A., Boccarelli, A., Giordano, D., Cardellicchio, N., Intini, F. ... Paradiso, A. (1999). In vitro antitumour activity and cellular pharmacological properties of the platinum-iminoether complex trans-[PtCl2[E-HN=C(OMe)Me]2].. International Journal of Oncology, 15, 1039-1083. https://doi.org/10.3892/ijo.15.5.1039
MLA
Coluccia, M., Nassi, A., Boccarelli, A., Giordano, D., Cardellicchio, N., Intini, F., Natile, G., Barletta, A., Paradiso, A."In vitro antitumour activity and cellular pharmacological properties of the platinum-iminoether complex trans-[PtCl2[E-HN=C(OMe)Me]2].". International Journal of Oncology 15.5 (1999): 1039-1083.
Chicago
Coluccia, M., Nassi, A., Boccarelli, A., Giordano, D., Cardellicchio, N., Intini, F., Natile, G., Barletta, A., Paradiso, A."In vitro antitumour activity and cellular pharmacological properties of the platinum-iminoether complex trans-[PtCl2[E-HN=C(OMe)Me]2].". International Journal of Oncology 15, no. 5 (1999): 1039-1083. https://doi.org/10.3892/ijo.15.5.1039