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NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours.

  • Authors:
    • A Meneghetti
    • E Mariani
    • S Santi
    • M Riccio
    • L Cattini
    • S Paoletti
    • A Facchini

  • View Affiliations

  • Published online on: November 1, 1999     https://doi.org/10.3892/ijo.15.5.909
  • Pages: 909-923
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Abstract

Osteosarcoma cell lines are differently lysed by natural killer (NK) lymphocytes. A critical step in the lytic process is the recognition and attachment of effector to target cells. To determine binding capacity and lytic activity of NK cells, we investigated the distribution and role of ICAM-1, 2 and 3 on two osteosarcoma cell lines (HOS and Saos-2) in basal conditions and after TNFalpha treatment. Modulation of ICAM-1 after TNFalpha treatment modified the binding capacity of NK cells to osteosarcoma target cells. This modulation process appears to play a critical role in determining the susceptibility of these cells to NK-mediated lysis.

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Journal Cover

Nov 1999
Volume 15 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Meneghetti A, Mariani E, Santi S, Riccio M, Cattini L, Paoletti S and Facchini A: NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours.. Int J Oncol 15: 909-923, 1999.
APA
Meneghetti, A., Mariani, E., Santi, S., Riccio, M., Cattini, L., Paoletti, S., & Facchini, A. (1999). NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours.. International Journal of Oncology, 15, 909-923. https://doi.org/10.3892/ijo.15.5.909
MLA
Meneghetti, A., Mariani, E., Santi, S., Riccio, M., Cattini, L., Paoletti, S., Facchini, A."NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours.". International Journal of Oncology 15.5 (1999): 909-923.
Chicago
Meneghetti, A., Mariani, E., Santi, S., Riccio, M., Cattini, L., Paoletti, S., Facchini, A."NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours.". International Journal of Oncology 15, no. 5 (1999): 909-923. https://doi.org/10.3892/ijo.15.5.909