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Peroxisome proliferator-activated receptor gamma activation in human breast cancer.

  • Authors:
    • L D Yee
    • C L Sabourin
    • L Liu
    • H M Li
    • P J Smith
    • V Seewaldt
    • D A Kniss

  • View Affiliations

  • Published online on: November 1, 1999     https://doi.org/10.3892/ijo.15.5.967
  • Pages: 967-1040
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Abstract

The peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor family of ligand-activated transcription factors. This study was designed to evaluate ligand activation of PPARgamma in human breast cancer cells. DNA binding by endogenous PPARgamma in gel shift assays and activation of PPARgamma by prostanoid and thiazolidinedione ligands in reporter gene assays differed between the cell lines. The PPARgamma ligands elicited an anti-proliferative effect in MTT proliferation assays. Our data point to a variable, cell-specific response to different gamma-ligands, which holds significance for further studies on the role of PPARgamma in mediating breast cancer growth and progression.

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Journal Cover

Nov 1999
Volume 15 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Yee L, Sabourin C, Liu L, Li H, Smith P, Seewaldt V and Kniss D: Peroxisome proliferator-activated receptor gamma activation in human breast cancer.. Int J Oncol 15: 967-1040, 1999.
APA
Yee, L., Sabourin, C., Liu, L., Li, H., Smith, P., Seewaldt, V., & Kniss, D. (1999). Peroxisome proliferator-activated receptor gamma activation in human breast cancer.. International Journal of Oncology, 15, 967-1040. https://doi.org/10.3892/ijo.15.5.967
MLA
Yee, L., Sabourin, C., Liu, L., Li, H., Smith, P., Seewaldt, V., Kniss, D."Peroxisome proliferator-activated receptor gamma activation in human breast cancer.". International Journal of Oncology 15.5 (1999): 967-1040.
Chicago
Yee, L., Sabourin, C., Liu, L., Li, H., Smith, P., Seewaldt, V., Kniss, D."Peroxisome proliferator-activated receptor gamma activation in human breast cancer.". International Journal of Oncology 15, no. 5 (1999): 967-1040. https://doi.org/10.3892/ijo.15.5.967