Cisplatin-induced p53-independent growth arrest and cell death in cancer cells.

  • Authors:
    • X Wang
    • Y Liu
    • L S Chow
    • S C Wong
    • S W Tsao
    • D L Kwong
    • J Wang
    • J S Sham
    • J M Nicholls
  • View Affiliations

  • Published online on: December 1, 1999     https://doi.org/10.3892/ijo.15.6.1097
  • Pages: 1097-1199
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Abstract

In a recent study, it was shown that DNA damaging agent cisplatin-induced growth arrest and cell death in cancer cells by a pathway sharing some of the characteristics of replicative senescence. The aim of this study was to determine the role of p53, p21WAF1 and p16INK4A proteins in this alternative route to cancer cell death in additional human cancer cell lines. After exposure to cisplatin, all the cell lines underwent growth arrest and expressed the senescence marker senescence-associated beta-galactosidase, but showed none of the features of apoptosis. However, there was no change in p53 protein expression, and neither p21WAF1 nor p16INK4A was expressed before or up to 4 days after cisplatin exposure. These findings provide further evidence that cells carrying mutations resulting in loss of function in the p53 gene can be killed by cisplatin via a p53-independent route with some similarities to replicative senescence, but not apoptosis.

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Dec 1999
Volume 15 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Wang X, Liu Y, Chow L, Wong S, Tsao S, Kwong D, Wang J, Sham J and Nicholls J: Cisplatin-induced p53-independent growth arrest and cell death in cancer cells.. Int J Oncol 15: 1097-1199, 1999.
APA
Wang, X., Liu, Y., Chow, L., Wong, S., Tsao, S., Kwong, D. ... Nicholls, J. (1999). Cisplatin-induced p53-independent growth arrest and cell death in cancer cells.. International Journal of Oncology, 15, 1097-1199. https://doi.org/10.3892/ijo.15.6.1097
MLA
Wang, X., Liu, Y., Chow, L., Wong, S., Tsao, S., Kwong, D., Wang, J., Sham, J., Nicholls, J."Cisplatin-induced p53-independent growth arrest and cell death in cancer cells.". International Journal of Oncology 15.6 (1999): 1097-1199.
Chicago
Wang, X., Liu, Y., Chow, L., Wong, S., Tsao, S., Kwong, D., Wang, J., Sham, J., Nicholls, J."Cisplatin-induced p53-independent growth arrest and cell death in cancer cells.". International Journal of Oncology 15, no. 6 (1999): 1097-1199. https://doi.org/10.3892/ijo.15.6.1097