Suppression of metastasis by tissue inhibitor of metalloproteinase-1 in a newly established human oral squamous cell carcinoma cell line.

Nii,M; Kayada,Y; Yoshiga,K; Takada,K; Okamoto,T; Yanagihara,K

doi:10.3892/ijo.16.1.119

Suppression of metastasis by tissue inhibitor of metalloproteinase-1 in a newly established human oral squamous cell carcinoma cell line.

Authors:
- M Nii
- Y Kayada
- K Yoshiga
- K Takada
- T Okamoto
- K Yanagihara
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Affiliations: Department of Molecular Oral Medicine and Maxillofacial Surgery I, Hiroshima University, School of Dentistry, Minami-ku, Hiroshima 734-8553, Japan.
Published online on: January 1, 2000 https://doi.org/10.3892/ijo.16.1.119
Pages: 119-143

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Abstract

We have established a highly-metastatic cell line (designated as HNOS) and a non-metastatic cell line (designated as SAT) derived from human oral cavity squamous cell carcinoma (SCC). Both lines were transplantable in nude mice. The invasive activity through Matrigel-coated membrane of HNOS cells was also higher than that of SAT cells. mRNA of TIMP-1 was expressed in SAT cells but not in HNOS cells. Metastatic and invasive abilities were suppressed by the overexpression of TIMP-1 in HNOS cells. These results suggest that TIMP-1 may have an important role in inhibiting invasion and metastasis of human oral cavity SCC.