search button

Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1.

  • Authors:
    • M Pospisil
    • L Vannucci
    • O Horvath
    • A Fiserova
    • K Krausova
    • K Bezouska
    • F Mosca

  • View Affiliations

  • Published online on: February 1, 2000     https://doi.org/10.3892/ijo.16.2.267
  • Pages: 267-343
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Natural killer (NK) and T cells express a superfamily of proteins with structural features of C-type lectins. Recombinantly prepared soluble form of rat NKR-P1 (CD161) recognized carbohydrate GalNac and GlcNac moieties. Ganglioside GM2 and heparin related-IS oligosaccharides representing the high affinity ligands for this receptor, increased the sensitivity of targets for killing by the rat effectors isolated from blood and spleen in vitro. Based on these results, we investigated in vivo the possible therapeutic effect of GM2 and IS carried by liposomes during induced rat colorectal carcinogenesis. The reduction of cancer incidence versus the controls (50% vs 88.88%), approached the 5-fluorouracil treatment (41.66%).

Related Articles

Journal Cover

Feb 2000
Volume 16 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Pospisil M, Vannucci L, Horvath O, Fiserova A, Krausova K, Bezouska K and Mosca F: Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1.. Int J Oncol 16: 267-343, 2000.
APA
Pospisil, M., Vannucci, L., Horvath, O., Fiserova, A., Krausova, K., Bezouska, K., & Mosca, F. (2000). Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1.. International Journal of Oncology, 16, 267-343. https://doi.org/10.3892/ijo.16.2.267
MLA
Pospisil, M., Vannucci, L., Horvath, O., Fiserova, A., Krausova, K., Bezouska, K., Mosca, F."Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1.". International Journal of Oncology 16.2 (2000): 267-343.
Chicago
Pospisil, M., Vannucci, L., Horvath, O., Fiserova, A., Krausova, K., Bezouska, K., Mosca, F."Cancer immunomodulation by carbohydrate ligands for the lymphocyte receptor NKR-P1.". International Journal of Oncology 16, no. 2 (2000): 267-343. https://doi.org/10.3892/ijo.16.2.267