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Expression in hepatomas and chromosomal localization of rat protein phosphatase 5 gene.

  • Authors:
    • H Shirato
    • H Shima
    • H Nakagama
    • H Fukuda
    • Y Watanabe
    • K Ogawa
    • Y Matsuda
    • K Kikuchi

  • View Affiliations

  • Published online on: November 1, 2000     https://doi.org/10.3892/ijo.17.5.909
  • Pages: 909-921
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Abstract

The serine/threonine protein phosphatase type 5 (PP5) gene expression was ubiquitously observed among all the tissues examined, but being at the lowest level in the liver. The levels of PP5 mRNA were markedly elevated in rat highly malignant ascites hepatomas, while those in several rat primary hepatomas were slightly increased and those in the regenerating livers were not elevated at all compared to the control liver. The PP5 gene was mapped to rat chromosome 1q22.1. This region has been identified to have linkage homology among human, mouse and rat, and is known to be associated with several tumor types. Taken together, the present results strongly suggest important roles of PP5 in tumorigenesis.

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Nov 2000
Volume 17 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • CiteScore: 9.6
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  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Shirato H, Shima H, Nakagama H, Fukuda H, Watanabe Y, Ogawa K, Matsuda Y and Kikuchi K: Expression in hepatomas and chromosomal localization of rat protein phosphatase 5 gene.. Int J Oncol 17: 909-921, 2000.
APA
Shirato, H., Shima, H., Nakagama, H., Fukuda, H., Watanabe, Y., Ogawa, K. ... Kikuchi, K. (2000). Expression in hepatomas and chromosomal localization of rat protein phosphatase 5 gene.. International Journal of Oncology, 17, 909-921. https://doi.org/10.3892/ijo.17.5.909
MLA
Shirato, H., Shima, H., Nakagama, H., Fukuda, H., Watanabe, Y., Ogawa, K., Matsuda, Y., Kikuchi, K."Expression in hepatomas and chromosomal localization of rat protein phosphatase 5 gene.". International Journal of Oncology 17.5 (2000): 909-921.
Chicago
Shirato, H., Shima, H., Nakagama, H., Fukuda, H., Watanabe, Y., Ogawa, K., Matsuda, Y., Kikuchi, K."Expression in hepatomas and chromosomal localization of rat protein phosphatase 5 gene.". International Journal of Oncology 17, no. 5 (2000): 909-921. https://doi.org/10.3892/ijo.17.5.909