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Gene expression of angiogenesis related factors in glioma

  • Authors:
    • Hideo Osada
    • Tetsuji Tokunaga
    • Hiroyuki Hatanaka
    • Tsutomu Kawakami
    • Takashi Tsuchida
    • Yoshiyuki Abe
    • Atsushi Tsugu
    • Hiroshi Kijima
    • Hitoshi Yamazaki
    • Katsuji Shima
    • Yoshiyuki Osamura
    • Yoshito Ueyama
    • Masato Nakamura

  • View Affiliations

  • Published online on: February 1, 2001     https://doi.org/10.3892/ijo.18.2.305
  • Pages: 305-309
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Abstract

Angiogenesis plays an important role in growth and proliferation of cancer. Various angiogenic and angiostatic factors regulate angiogenesis. In this study, we examined gene expression of the angiopoietin family including angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2) in 39 gliomas and 5 glioma-xenografts by RT-PCR. Ang1 and Ang2 genes were expressed in 54%, and 77% of gliomas, respectively. The expression of Ang1 was significantly correlated with the expression of Ang2. Both Ang1 and Ang2 were shown to be expressed in the glioma cells. Ang2 gene expression was correlated with VEGF gene expression. Angiopoietin molecules may synergistically cooperate in growth and vascularization in glioma.

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Journal Cover

February 2001
Volume 18 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Osada H, Tokunaga T, Hatanaka H, Kawakami T, Tsuchida T, Abe Y, Tsugu A, Kijima H, Yamazaki H, Shima K, Shima K, et al: Gene expression of angiogenesis related factors in glioma. Int J Oncol 18: 305-309, 2001.
APA
Osada, H., Tokunaga, T., Hatanaka, H., Kawakami, T., Tsuchida, T., Abe, Y. ... Nakamura, M. (2001). Gene expression of angiogenesis related factors in glioma. International Journal of Oncology, 18, 305-309. https://doi.org/10.3892/ijo.18.2.305
MLA
Osada, H., Tokunaga, T., Hatanaka, H., Kawakami, T., Tsuchida, T., Abe, Y., Tsugu, A., Kijima, H., Yamazaki, H., Shima, K., Osamura, Y., Ueyama, Y., Nakamura, M."Gene expression of angiogenesis related factors in glioma". International Journal of Oncology 18.2 (2001): 305-309.
Chicago
Osada, H., Tokunaga, T., Hatanaka, H., Kawakami, T., Tsuchida, T., Abe, Y., Tsugu, A., Kijima, H., Yamazaki, H., Shima, K., Osamura, Y., Ueyama, Y., Nakamura, M."Gene expression of angiogenesis related factors in glioma". International Journal of Oncology 18, no. 2 (2001): 305-309. https://doi.org/10.3892/ijo.18.2.305