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A candidate tumor suppressor locus for scirrhous gastric cancer at chromosome 18q12.2

  • Authors:
    • N. Nishioka
    • M. Yashiro
    • T. Inoue
    • T. Matsuoka
    • M. Ohira
    • K. Hirakawa-YS Chung

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  • Published online on: February 1, 2001     https://doi.org/10.3892/ijo.18.2.317
  • Pages: 317-322
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Abstract

We investigated LOH on 5q, 16q, 17p, 17q, and 18q in scirrhous gastric cancer and identified the chromosomal locus that is frequently deleted in scirrhous gastric cancer. LOH frequency on 18q of scirrhous gastric cancer was found to be significantly higher than that of the other types of advanced gastric cancer, while no significant difference between LOH at 5q, 16q, 17p and 17q was found. Eight microsatellite markers on chromosome 18q were additionally examined in scirrhous gastric cancer. The highest rates of LOH were observed at the D18S34 locus which is located at 18q12.2. These findings suggest that the D18S34 locus might be a novel candidate tumor suppressor locus in scirrhous gastric carcinoma.

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Journal Cover

February 2001
Volume 18 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Nishioka N, Yashiro M, Inoue T, Matsuoka T, Ohira M and Hirakawa-YS Chung K: A candidate tumor suppressor locus for scirrhous gastric cancer at chromosome 18q12.2. Int J Oncol 18: 317-322, 2001.
APA
Nishioka, N., Yashiro, M., Inoue, T., Matsuoka, T., Ohira, M., & Hirakawa-YS Chung, K. (2001). A candidate tumor suppressor locus for scirrhous gastric cancer at chromosome 18q12.2. International Journal of Oncology, 18, 317-322. https://doi.org/10.3892/ijo.18.2.317
MLA
Nishioka, N., Yashiro, M., Inoue, T., Matsuoka, T., Ohira, M., Hirakawa-YS Chung, K."A candidate tumor suppressor locus for scirrhous gastric cancer at chromosome 18q12.2". International Journal of Oncology 18.2 (2001): 317-322.
Chicago
Nishioka, N., Yashiro, M., Inoue, T., Matsuoka, T., Ohira, M., Hirakawa-YS Chung, K."A candidate tumor suppressor locus for scirrhous gastric cancer at chromosome 18q12.2". International Journal of Oncology 18, no. 2 (2001): 317-322. https://doi.org/10.3892/ijo.18.2.317