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Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas

  • Authors:
    • Hiroyuki Mutoh
    • Hiroshi Nagata
    • Kazuto Ohno
    • Tsutomu Numata
    • Toshitaka Nagao
    • Koichi Nagao
    • Akiyoshi Konno

  • View Affiliations

  • Published online on: April 1, 2001     https://doi.org/10.3892/ijo.18.4.781
  • Pages: 781-786
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Abstract

Mutations and overexpression of the p53 gene and protein were analyzed in 40 cases with various types of parotid gland cancers. Mutations were found in 12 cases (30%), and low-grade mucoepidermoid carcinomas (43%) and highly malignant carcinomas including adenocarcinoma, salivary duct carcinoma, and undifferentiated carcinoma (56%) showed a relatively high frequency of mutations. Overexpression of the protein was observed in 11 cases (28%) and 4 of the 11 cases also had p53 mutations. These results suggest that mutations of the p53 gene have significance in certain types of parotid cancers irrespective of the aggressiveness of a tumor type.

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Journal Cover

April 2001
Volume 18 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Mutoh H, Nagata H, Ohno K, Numata T, Nagao T, Nagao K and Konno A: Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas. Int J Oncol 18: 781-786, 2001.
APA
Mutoh, H., Nagata, H., Ohno, K., Numata, T., Nagao, T., Nagao, K., & Konno, A. (2001). Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas. International Journal of Oncology, 18, 781-786. https://doi.org/10.3892/ijo.18.4.781
MLA
Mutoh, H., Nagata, H., Ohno, K., Numata, T., Nagao, T., Nagao, K., Konno, A."Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas". International Journal of Oncology 18.4 (2001): 781-786.
Chicago
Mutoh, H., Nagata, H., Ohno, K., Numata, T., Nagao, T., Nagao, K., Konno, A."Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas". International Journal of Oncology 18, no. 4 (2001): 781-786. https://doi.org/10.3892/ijo.18.4.781