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Microsatellite and chromosome instability in squamous cell laryngeal carcinoma

  • Authors:
    • Maria Sasiadek
    • Agnieszka Stembalska-Kozlowska
    • Robert Smigiel
    • Tomasz Krecicki
    • Nikolaus Blin
    • Farhad Mirghomizadeh

  • View Affiliations

  • Published online on: August 1, 2001     https://doi.org/10.3892/ijo.19.2.401
  • Pages: 401-405
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Abstract

Head-and neck squamous cell carcinoma (HNSCC) represents almost 5% of all malignancies in Europe. The aetiology of HNSCC is complex, with both genetic and mutagenic factors involved. The aim of the present study was to investigate the loss of heterozygosity (LOH), mainly at tumour suppressor loci (using markers D1S2883, D2S123, D3S1611, D5S346, D7S501, D8S254, TP53, NM23), microsatellite instability (BAT25, 26, 40) and (bleomycin test) in patients with squamous cell larynx cancer. In a group of 20 patients LOH was observed mainly at the loci 3p (64.7%), 8q (71.4%), 17q (M1-30.8%, M2-25%, M3-38.5%). Despite chromosomal instability detected by bleomycin no microsatellite instability was observed.

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Journal Cover

August 2001
Volume 19 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Sasiadek M, Stembalska-Kozlowska A, Smigiel R, Krecicki T, Blin N and Mirghomizadeh F: Microsatellite and chromosome instability in squamous cell laryngeal carcinoma. Int J Oncol 19: 401-405, 2001.
APA
Sasiadek, M., Stembalska-Kozlowska, A., Smigiel, R., Krecicki, T., Blin, N., & Mirghomizadeh, F. (2001). Microsatellite and chromosome instability in squamous cell laryngeal carcinoma. International Journal of Oncology, 19, 401-405. https://doi.org/10.3892/ijo.19.2.401
MLA
Sasiadek, M., Stembalska-Kozlowska, A., Smigiel, R., Krecicki, T., Blin, N., Mirghomizadeh, F."Microsatellite and chromosome instability in squamous cell laryngeal carcinoma". International Journal of Oncology 19.2 (2001): 401-405.
Chicago
Sasiadek, M., Stembalska-Kozlowska, A., Smigiel, R., Krecicki, T., Blin, N., Mirghomizadeh, F."Microsatellite and chromosome instability in squamous cell laryngeal carcinoma". International Journal of Oncology 19, no. 2 (2001): 401-405. https://doi.org/10.3892/ijo.19.2.401