TGF-β1 promotes liver metastasis of pancreatic cancer by modulating the capacity of cellular invasion

Teraoka,H.; Sawada,T.; Yamashita,Y.; Nakata,B.; Ohira,M.; Ishikawa,T.; Nishino,H.; Hirakawa,K.

doi:10.3892/ijo.19.4.709

TGF-β1 promotes liver metastasis of pancreatic cancer by modulating the capacity of cellular invasion

Authors:
- H. Teraoka
- T. Sawada
- Y. Yamashita
- B. Nakata
- M. Ohira
- T. Ishikawa
- H. Nishino
- K. Hirakawa
View Affiliations

Affiliations: First Department of Surgery, Osaka City University Medical School, Osaka 545-8585, Japan
Published online on: October 1, 2001 https://doi.org/10.3892/ijo.19.4.709
Pages: 709-715

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Abstract

We investigated the effect of TGF-β1 on liver metastasis of pancreatic cancer using surgical specimens of pancreatic cancer and human pancreatic cancer cell lines Capan-2 and SW1990. Immunostaining of TGF-β1 showed that TGF-β1 positivity was significantly related to venous invasion and tumor staging, and also relatively associated with liver metastasis. Cellular invasion and protease production of MMP-2 and u-PA, and in vivo liver metastasis were significantly enhanced after treatment of cells with TGF-β1. These findings suggest that TGF-β1 might play an important role in enhancing liver metastasis of pancreatic cancer.