P-GLYCOPROTEIN - LOW CONSTITUTIONAL EXPRESSION DOES NOT CORRELATE WITH TREATMENT FAILURE IN FOLLICULAR LYMPHOMAS
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- Published online on: June 1, 1993 https://doi.org/10.3892/ijo.2.6.1067
- Pages: 1067-1070
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Abstract
Tissue P-glycoprotein immunostaining was performed in seventy one patients with follicular large, mixed, or small cell non-Hodgkin's lymphomas. Only six patients (8.5%) demonstrated positive immunostaining for P-glycoprotein. All patients had complete and durable responses to initial therapy. P-glycoprotein (MDR) fails to predict for primary drug resistance in follicular lymphomas and is constitutionally expressed in only a few follicular lymphomas at present.