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Cadmium-induced neoplastic transformation of human prostate epithelial cells

  • Authors:
    • Keiichiro Nakamura
    • Yutaka Yasunaga
    • Daejin Ko
    • Linda L. Xu
    • Judd W. Moul
    • Donna M. Peehl
    • Shiv Srivastava
    • Johng S. Rhim

  • View Affiliations

  • Published online on: March 1, 2002     https://doi.org/10.3892/ijo.20.3.543
  • Pages: 543-547
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Abstract

Cadmium is a ubiquitous environmental human carcinogen. Epidemiological and animal studies have suggested its carcinogenic potential on the prostate. In the present study, non-tumorigenic human prostate epithelial cells (pRNS-1-1) immortalized by simian papovavirus (SV40) were transformed after repeated exposures to cadmium. Such transformants showed morphological alterations, anchorage-independent growth in soft agar, and formed tumors when transplanted into SCID mice. The tumors were characterized histologically as poorly-differentiated adenocarcinomas, expressing prostate-specific antigen (PSA), androgen receptor (AR), prostate stem cell antigen (PSCA), NKX3.1 and cytokeratin 8 (CK8). These findings provide evidence of malignant transformation of human prostate epithelial cells exposed to this environmentally important chemical.

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Journal Cover

March 2002
Volume 20 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Nakamura K, Yasunaga Y, Ko D, Xu LL, Moul JW, Peehl DM, Srivastava S and Rhim JS: Cadmium-induced neoplastic transformation of human prostate epithelial cells. Int J Oncol 20: 543-547, 2002.
APA
Nakamura, K., Yasunaga, Y., Ko, D., Xu, L.L., Moul, J.W., Peehl, D.M. ... Rhim, J.S. (2002). Cadmium-induced neoplastic transformation of human prostate epithelial cells. International Journal of Oncology, 20, 543-547. https://doi.org/10.3892/ijo.20.3.543
MLA
Nakamura, K., Yasunaga, Y., Ko, D., Xu, L. L., Moul, J. W., Peehl, D. M., Srivastava, S., Rhim, J. S."Cadmium-induced neoplastic transformation of human prostate epithelial cells". International Journal of Oncology 20.3 (2002): 543-547.
Chicago
Nakamura, K., Yasunaga, Y., Ko, D., Xu, L. L., Moul, J. W., Peehl, D. M., Srivastava, S., Rhim, J. S."Cadmium-induced neoplastic transformation of human prostate epithelial cells". International Journal of Oncology 20, no. 3 (2002): 543-547. https://doi.org/10.3892/ijo.20.3.543