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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2011 Volume 39 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2011 Volume 39 Issue 4

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Article

Expression of CLDN1 in colorectal cancer: A novel marker for prognosis

  • Authors:
    • Sumiko Nakagawa
    • Norikatsu Miyoshi
    • Hideshi Ishii
    • Koshi Mimori
    • Fumiaki Tanaka
    • Mitsugu Sekimoto
    • Yuichiro Doki
    • Masaki Mori

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, Japan, Yamadaoka, Suita 2-2, Osaka 565-0871, Japan
  • Pages: 791-796
    |
    Published online on: June 28, 2011
       https://doi.org/10.3892/ijo.2011.1102
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Abstract

Claudin1 (CLDN1) plays an important role not only in the intercellular barrier function of tight junctions (TJs) but also in migration and invasiveness of cancer cells. Previous reports show that CLDN1 overexpression is significantly related to the malignant behavior in several cancer types whereas its significance in colorectal cancer (CRC) is not fully understood. The present study comprised 119 patients who underwent surgery for CRC, as well as 3 cell lines derived from human CRC. The correlation of gene expression with clinical parameters in patients was assessed by knockdown experiments using 3 cell lines. Patients with high CLDN1 expression were statistically shown to have a relatively better prognosis, and those with low CLDN1 expression showed poorer overall survival and disease-free survival than those with high expression. The assessment of CLDN1 knockdown in the 3 cell lines demonstrated that the siRNA inhibition resulted in a statistically significant increase in cell invasiveness. In conclusion, the present data strongly suggest that CLDN1 expression is a prognostic factor in CRC patients.

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Copy and paste a formatted citation
Spandidos Publications style
Nakagawa S, Miyoshi N, Ishii H, Mimori K, Tanaka F, Sekimoto M, Doki Y and Mori M: Expression of CLDN1 in colorectal cancer: A novel marker for prognosis. Int J Oncol 39: 791-796, 2011.
APA
Nakagawa, S., Miyoshi, N., Ishii, H., Mimori, K., Tanaka, F., Sekimoto, M. ... Mori, M. (2011). Expression of CLDN1 in colorectal cancer: A novel marker for prognosis. International Journal of Oncology, 39, 791-796. https://doi.org/10.3892/ijo.2011.1102
MLA
Nakagawa, S., Miyoshi, N., Ishii, H., Mimori, K., Tanaka, F., Sekimoto, M., Doki, Y., Mori, M."Expression of CLDN1 in colorectal cancer: A novel marker for prognosis". International Journal of Oncology 39.4 (2011): 791-796.
Chicago
Nakagawa, S., Miyoshi, N., Ishii, H., Mimori, K., Tanaka, F., Sekimoto, M., Doki, Y., Mori, M."Expression of CLDN1 in colorectal cancer: A novel marker for prognosis". International Journal of Oncology 39, no. 4 (2011): 791-796. https://doi.org/10.3892/ijo.2011.1102
Copy and paste a formatted citation
x
Spandidos Publications style
Nakagawa S, Miyoshi N, Ishii H, Mimori K, Tanaka F, Sekimoto M, Doki Y and Mori M: Expression of CLDN1 in colorectal cancer: A novel marker for prognosis. Int J Oncol 39: 791-796, 2011.
APA
Nakagawa, S., Miyoshi, N., Ishii, H., Mimori, K., Tanaka, F., Sekimoto, M. ... Mori, M. (2011). Expression of CLDN1 in colorectal cancer: A novel marker for prognosis. International Journal of Oncology, 39, 791-796. https://doi.org/10.3892/ijo.2011.1102
MLA
Nakagawa, S., Miyoshi, N., Ishii, H., Mimori, K., Tanaka, F., Sekimoto, M., Doki, Y., Mori, M."Expression of CLDN1 in colorectal cancer: A novel marker for prognosis". International Journal of Oncology 39.4 (2011): 791-796.
Chicago
Nakagawa, S., Miyoshi, N., Ishii, H., Mimori, K., Tanaka, F., Sekimoto, M., Doki, Y., Mori, M."Expression of CLDN1 in colorectal cancer: A novel marker for prognosis". International Journal of Oncology 39, no. 4 (2011): 791-796. https://doi.org/10.3892/ijo.2011.1102
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