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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2011 Volume 39 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2011 Volume 39 Issue 6

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Article

A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions

  • Authors:
    • Hiroshi Inoue
    • Yuichi Ohnishi
    • Masahiro Nakajima
    • Kenji Kakudo
    • Masami Nozaki

  • View Affiliations / Copyright

    Affiliations: Second Department of Oral and Maxillofacial Surgery, Osaka Dental University, 1-5-17 Otemae, Chuo-ku 540-0008, Japan, Department of Cell Biology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, Japan
  • Pages: 1401-1405
    |
    Published online on: July 22, 2011
       https://doi.org/10.3892/ijo.2011.1137
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Abstract

Epithelial cell adhesion molecule (EpCAM), involved in Ca2+-independent homotypic cell-cell adhesion in epithelial tissues, is overexpressed in several cancer types. Although studies investigating the function of EpCAM in cancers have shown that it plays a role in cell proliferation, invasion and metastasis, the overall function of EpCAM in cancer cells has remained elusive. Here, we report a novel function of EpCAM in multicellular aggregates (MCAs). EpCAM inhibition using RNA interference (RNAi) did not affect cell morphology, proliferation or expression of certain genes, including cyclin D1 in monolayer cultures of the human oral squamous cell carcinoma cell lines HSC-3 or HSC-4. However, in HSC-4 cells cultured as MCAs, suppression of EpCAM significantly reduced the expression levels of cyclin D1. Nuclear localization of the cyclin D1 protein was observed in MCAs of HSC-4 cells but not in MCAs of EpCAM knockdown HSC4 cells, suggesting that EpCAM regulates cyclin D1 expression and localization in HSC-4 cells under anchorage-independent conditions. We propose that targeting EpCAM might result in more efficient therapies under certain conditions of oral squamous cell carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Inoue H, Ohnishi Y, Nakajima M, Kakudo K and Nozaki M: A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions. Int J Oncol 39: 1401-1405, 2011.
APA
Inoue, H., Ohnishi, Y., Nakajima, M., Kakudo, K., & Nozaki, M. (2011). A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions. International Journal of Oncology, 39, 1401-1405. https://doi.org/10.3892/ijo.2011.1137
MLA
Inoue, H., Ohnishi, Y., Nakajima, M., Kakudo, K., Nozaki, M."A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions". International Journal of Oncology 39.6 (2011): 1401-1405.
Chicago
Inoue, H., Ohnishi, Y., Nakajima, M., Kakudo, K., Nozaki, M."A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions". International Journal of Oncology 39, no. 6 (2011): 1401-1405. https://doi.org/10.3892/ijo.2011.1137
Copy and paste a formatted citation
x
Spandidos Publications style
Inoue H, Ohnishi Y, Nakajima M, Kakudo K and Nozaki M: A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions. Int J Oncol 39: 1401-1405, 2011.
APA
Inoue, H., Ohnishi, Y., Nakajima, M., Kakudo, K., & Nozaki, M. (2011). A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions. International Journal of Oncology, 39, 1401-1405. https://doi.org/10.3892/ijo.2011.1137
MLA
Inoue, H., Ohnishi, Y., Nakajima, M., Kakudo, K., Nozaki, M."A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions". International Journal of Oncology 39.6 (2011): 1401-1405.
Chicago
Inoue, H., Ohnishi, Y., Nakajima, M., Kakudo, K., Nozaki, M."A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions". International Journal of Oncology 39, no. 6 (2011): 1401-1405. https://doi.org/10.3892/ijo.2011.1137
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