[Corrigendum] HIF-1α contributes to tube malformation of human lymphatic endothelial cells by upregulating VEGFR-3

• Authors:
  • Tao Han
  • Jun Yan
  • Haini Chen
  • Yi Ji
  • Jianbing Chen
  • Jie Cui
  • Weimin Shen
  • Jijun Zou

• View Affiliations

  
  Affiliations: Department of Burns and Plastic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China
• Published online on: August 1, 2022     https://doi.org/10.3892/ijo.2022.5403
• Article Number: 113

• Copyright : © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

Article

Int J Oncol 54: [Related article:] 139-151, 2019; DOI: 10.3892/ijo.2018.4623

Subsequently to the publication of the above article, the authors have realized that Fig. 4 on p. 145 (showing the results from the colony formation assay) was published containing erroneous images in Fig. 4C. Essentially, incorrect images were selected to represent the negative control (NC) experiments owing to an altered shooting angle and incorrect naming of the files.

Figure 4 Effects of HIF-1α knockdown on HLEC colony formation and migration. (A) Relative mRNA expression of HIF-1α and VEGFR-3 in HLECs transfected with and short interfering RNA targeting HIF-1α. (B) HIF-1α and VEGFR-3 protein expression, (C) colony formation and (D) wound-healing assays (magnification, ×100) for HIF-1α knockdown and NC groups. Experiments were repeated ≥3 times with similar results and data are presented as mean ± standard deviation. *P<0.05 and **P<0.01 vs. NC. HLEC, human lymphatic endothelial cell; HIF-1α, hypoxia-inducible factor-1α; VEGF, vascular endothelial growth factor; NC, negative control.

The corrected version of Fig. 4, now showing the correct data for the NC experiments in Fig. 4C, is shown on the next page. The authors confirm that the error made in the presentation of Fig. 4 did not adversely affect either the results or the conclusions reported in this paper, and they are grateful to the Editor of International Journal of Oncology for granting them this opportunity to publish a Corrigendum. They also apologise to the readership for any inconvenience caused.

Figure 4 Effects of HIF-1α knockdown on HLEC colony formation and migration. (A) Relative mRNA expression of HIF-1α and VEGFR-3 in HLECs transfected with and short interfering RNA targeting HIF-1α. (B) HIF-1α and VEGFR-3 protein expression, (C) colony formation and (D) wound-healing assays (magnification, ×100) for HIF-1α knockdown and NC groups. Experiments were repeated ≥3 times with similar results and data are presented as mean ± standard deviation. *P<0.05 and **P<0.01 vs. NC. HLEC, human lymphatic endothelial cell; HIF-1α, hypoxia-inducible factor-1α; VEGF, vascular endothelial growth factor; NC, negative control.