Open Access

Role of telomere length in human carcinogenesis (Review)

  • Authors:
    • Aristidis Tsatsakis
    • Tatiana Oikonomopoulou
    • Taxiarchis Konstantinos Nikolouzakis
    • Elena Vakonaki
    • Manolis Tzatzarakis
    • Matthaios Flamourakis
    • Elisavet Renieri
    • Persefoni Fragkiadaki
    • Evaggelia Iliaki
    • Maria Bachlitzanaki
    • Vasiliki Karzi
    • Ioanna Katsikantami
    • Fotios Kakridonis
    • Eleftheria Hatzidaki
    • Maria Tolia
    • Andrey A. Svistunov
    • Demetrios A. Spandidos
    • Dragana Nikitovic
    • John Tsiaoussis
    • Aikaterini Berdiaki
  • View Affiliations

  • Published online on: May 22, 2023     https://doi.org/10.3892/ijo.2023.5526
  • Article Number: 78
  • Copyright: © Tsatsakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer is considered the most important clinical, social and economic issue regarding cause‑specific disability‑adjusted life years among all human pathologies. Exogenous, endogenous and individual factors, including genetic predisposition, participate in cancer triggering. Telomeres are specific DNA structures positioned at the end of chromosomes and consist of repetitive nucleotide sequences, which, together with shelterin proteins, facilitate the maintenance of chromosome stability, while protecting them from genomic erosion. Even though the connection between telomere status and carcinogenesis has been identified, the absence of a universal or even a cancer‑specific trend renders consent even more complex. It is indicative that both short and long telomere lengths have been associated with a high risk of cancer incidence. When evaluating risk associations between cancer and telomere length, a disparity appears to emerge. Even though shorter telomeres have been adopted as a marker of poorer health status and an older biological age, longer telomeres due to increased cell growth potential are associated with the acquirement of cancer‑initiating somatic mutations. Therefore, the present review aimed to comprehensively present the multifaceted pattern of telomere length and cancer incidence association.
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July-2023
Volume 63 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Tsatsakis A, Oikonomopoulou T, Nikolouzakis TK, Vakonaki E, Tzatzarakis M, Flamourakis M, Renieri E, Fragkiadaki P, Iliaki E, Bachlitzanaki M, Bachlitzanaki M, et al: Role of telomere length in human carcinogenesis (Review). Int J Oncol 63: 78, 2023.
APA
Tsatsakis, A., Oikonomopoulou, T., Nikolouzakis, T.K., Vakonaki, E., Tzatzarakis, M., Flamourakis, M. ... Berdiaki, A. (2023). Role of telomere length in human carcinogenesis (Review). International Journal of Oncology, 63, 78. https://doi.org/10.3892/ijo.2023.5526
MLA
Tsatsakis, A., Oikonomopoulou, T., Nikolouzakis, T. K., Vakonaki, E., Tzatzarakis, M., Flamourakis, M., Renieri, E., Fragkiadaki, P., Iliaki, E., Bachlitzanaki, M., Karzi, V., Katsikantami, I., Kakridonis, F., Hatzidaki, E., Tolia, M., Svistunov, A. A., Spandidos, D. A., Nikitovic, D., Tsiaoussis, J., Berdiaki, A."Role of telomere length in human carcinogenesis (Review)". International Journal of Oncology 63.1 (2023): 78.
Chicago
Tsatsakis, A., Oikonomopoulou, T., Nikolouzakis, T. K., Vakonaki, E., Tzatzarakis, M., Flamourakis, M., Renieri, E., Fragkiadaki, P., Iliaki, E., Bachlitzanaki, M., Karzi, V., Katsikantami, I., Kakridonis, F., Hatzidaki, E., Tolia, M., Svistunov, A. A., Spandidos, D. A., Nikitovic, D., Tsiaoussis, J., Berdiaki, A."Role of telomere length in human carcinogenesis (Review)". International Journal of Oncology 63, no. 1 (2023): 78. https://doi.org/10.3892/ijo.2023.5526