Open Access

mRNA vaccine development and applications: A special focus on tumors (Review)

  • Authors:
    • Bangjie Chen
    • Yipin Yang
    • Xinyi Wang
    • Wenzhi Yang
    • You Lu
    • Daoyue Wang
    • Enba Zhuo
    • Yanchao Tang
    • Junhong Su
    • Guozheng Tang
    • Song Shao
    • Kangsheng Gu
  • View Affiliations

  • Published online on: July 9, 2024     https://doi.org/10.3892/ijo.2024.5669
  • Article Number: 81
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer is characterized by unlimited proliferation and metastasis, and traditional therapeutic strategies usually result in the acquisition of drug resistance, thus highlighting the need for more personalized treatment. mRNA vaccines transfer the gene sequences of exogenous target antigens into human cells through transcription and translation to stimulate the body to produce specific immune responses against the encoded proteins, so as to enable the body to obtain immune protection against said antigens; this approach may be adopted for personalized cancer therapy. Since the recent coronavirus pandemic, the development of mRNA vaccines has seen substantial progress and widespread adoption. In the present review, the development of mRNA vaccines, their mechanisms of action, factors influencing their function and the current clinical applications of the vaccine are discussed. A focus is placed on the application of mRNA vaccines in cancer, with the aim of highlighting unique advances and the remaining challenges of this novel and promising therapeutic approach.
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August-2024
Volume 65 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Chen B, Yang Y, Wang X, Yang W, Lu Y, Wang D, Zhuo E, Tang Y, Su J, Tang G, Tang G, et al: mRNA vaccine development and applications: A special focus on tumors (Review). Int J Oncol 65: 81, 2024.
APA
Chen, B., Yang, Y., Wang, X., Yang, W., Lu, Y., Wang, D. ... Gu, K. (2024). mRNA vaccine development and applications: A special focus on tumors (Review). International Journal of Oncology, 65, 81. https://doi.org/10.3892/ijo.2024.5669
MLA
Chen, B., Yang, Y., Wang, X., Yang, W., Lu, Y., Wang, D., Zhuo, E., Tang, Y., Su, J., Tang, G., Shao, S., Gu, K."mRNA vaccine development and applications: A special focus on tumors (Review)". International Journal of Oncology 65.2 (2024): 81.
Chicago
Chen, B., Yang, Y., Wang, X., Yang, W., Lu, Y., Wang, D., Zhuo, E., Tang, Y., Su, J., Tang, G., Shao, S., Gu, K."mRNA vaccine development and applications: A special focus on tumors (Review)". International Journal of Oncology 65, no. 2 (2024): 81. https://doi.org/10.3892/ijo.2024.5669