Bcl-xL overexpression in human hepatocellular carcinoma

  • Authors:
    • J. Watanabe
    • F. Kushihata
    • K. Honda
    • K. Mominoki
    • S. Matsuda
    • N. Kobayashi
  • View Affiliations

  • Published online on: September 1, 2002     https://doi.org/10.3892/ijo.21.3.515
  • Pages: 515-519
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Abstract

It is known that proliferation and apoptosis are closely related phenomena in liver cancer cells. In this study, using surgical specimens from 42 patients with hepatocellular carcinoma (HCC), we investigated the expression and localization of Bcl-xL, an antiapoptosis-related protein of the Bcl-2 family. Using Western blotting, Bcl-xL expression was detected in both cancerous and non-cancerous specimens from all of the HCC patients, and elevated Bcl-xL levels were found in cancerous specimens from two thirds of the patients. In normal human liver specimens, Bcl-xL was found mainly in the cytoplasm of hepatocytes, although it was also found in the cytoplasm of bile duct cells in Glisson's capsule by immunohistochemical staining. To the best of our knowledge, this is the first report of Bcl-xL overexpression and localization in HCC specimens. Bcl-xL was found not only in the cytoplasm of HCC cells, but also in the nuclei of some HCC cells, suggesting that Bcl-xL is involved in the progression of HCC cells in vivo.

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September 2002
Volume 21 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Watanabe J, Kushihata F, Honda K, Mominoki K, Matsuda S and Kobayashi N: Bcl-xL overexpression in human hepatocellular carcinoma. Int J Oncol 21: 515-519, 2002.
APA
Watanabe, J., Kushihata, F., Honda, K., Mominoki, K., Matsuda, S., & Kobayashi, N. (2002). Bcl-xL overexpression in human hepatocellular carcinoma. International Journal of Oncology, 21, 515-519. https://doi.org/10.3892/ijo.21.3.515
MLA
Watanabe, J., Kushihata, F., Honda, K., Mominoki, K., Matsuda, S., Kobayashi, N."Bcl-xL overexpression in human hepatocellular carcinoma". International Journal of Oncology 21.3 (2002): 515-519.
Chicago
Watanabe, J., Kushihata, F., Honda, K., Mominoki, K., Matsuda, S., Kobayashi, N."Bcl-xL overexpression in human hepatocellular carcinoma". International Journal of Oncology 21, no. 3 (2002): 515-519. https://doi.org/10.3892/ijo.21.3.515