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Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review)

  • Authors:
    • Fumin Chang
    • Linda S. Steelman
    • John G. Shelton
    • John T. Lee
    • Patrick M. Navolanic
    • William L. Blalock
    • Richard Franklin
    • James A. McCubrey

  • View Affiliations

  • Published online on: March 1, 2003     https://doi.org/10.3892/ijo.22.3.469
  • Pages: 469-480
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Abstract

The Ras/Raf/MEK/ERK signal transduction pathway regulates cell cycle progression and apoptosis in diverse types of cells. Mutations in this pathway are often observed in transformed cell lines and frequently linked with human cancers. The Ras/Raf/MEK/ERK pathway can induce events both associated with cell proliferation and cell cycle arrest. The particular course chosen may depend on the strength and the particular Raf gene activated by Ras. This pathway also is involved in maintaining cell survival by modulating the activity of apoptotic molecules including Bad and Bcl-2. This review will discuss the regulation of the Ras/Raf/MEK/ERK pathway and how it modulates cell cycle progression and cell survival.

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Journal Cover

March 2003
Volume 22 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Chang F, Steelman LS, Shelton JG, Lee JT, Navolanic PM, Blalock WL, Franklin R and McCubrey JA: Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review). Int J Oncol 22: 469-480, 2003.
APA
Chang, F., Steelman, L.S., Shelton, J.G., Lee, J.T., Navolanic, P.M., Blalock, W.L. ... McCubrey, J.A. (2003). Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review). International Journal of Oncology, 22, 469-480. https://doi.org/10.3892/ijo.22.3.469
MLA
Chang, F., Steelman, L. S., Shelton, J. G., Lee, J. T., Navolanic, P. M., Blalock, W. L., Franklin, R., McCubrey, J. A."Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review)". International Journal of Oncology 22.3 (2003): 469-480.
Chicago
Chang, F., Steelman, L. S., Shelton, J. G., Lee, J. T., Navolanic, P. M., Blalock, W. L., Franklin, R., McCubrey, J. A."Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review)". International Journal of Oncology 22, no. 3 (2003): 469-480. https://doi.org/10.3892/ijo.22.3.469