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Aberrant methylation in promoter-associated CpG islands of multiple genes in therapy-related leukemia

  • Authors:
    • Eisuke Uehara
    • Seisho Takeuchi
    • Taizo Tasaka
    • Yoshiko Matsuhashi
    • Yang Yang
    • Mitsuhiro Fujita
    • Takahiro Tamura
    • Masami Nagai
    • H. Phillip Koeffler

  • View Affiliations

  • Published online on: September 1, 2003     https://doi.org/10.3892/ijo.23.3.693
  • Pages: 693-696
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Abstract

Methylation profile was analyzed in eleven cases of therapy-related leukemia (t-leukemia) for p14, p15, p16, Rb, hMLH1, hMSH2, MGMT, APC, RAR β, DAPK, RIZ1, FHIT, and SOCS-1 genes by using methylation specific polymerase chain reaction (MSP) analysis. Six (55%) of eleven cases showed methylation of at least one gene. The average time to the development of t-leukemia after the treatment of the primary tumor was significantly shorter in patients with methylation than those without methylation (49.3 months vs. 133.2 months, P=0.044). These results suggest that hypermethylation might be involved in the development of t-leukemia.

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September 2003
Volume 23 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 4.5
  • Ranked Oncology
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Uehara E, Takeuchi S, Tasaka T, Matsuhashi Y, Yang Y, Fujita M, Tamura T, Nagai M and Koeffler HP: Aberrant methylation in promoter-associated CpG islands of multiple genes in therapy-related leukemia. Int J Oncol 23: 693-696, 2003.
APA
Uehara, E., Takeuchi, S., Tasaka, T., Matsuhashi, Y., Yang, Y., Fujita, M. ... Koeffler, H.P. (2003). Aberrant methylation in promoter-associated CpG islands of multiple genes in therapy-related leukemia. International Journal of Oncology, 23, 693-696. https://doi.org/10.3892/ijo.23.3.693
MLA
Uehara, E., Takeuchi, S., Tasaka, T., Matsuhashi, Y., Yang, Y., Fujita, M., Tamura, T., Nagai, M., Koeffler, H. P."Aberrant methylation in promoter-associated CpG islands of multiple genes in therapy-related leukemia". International Journal of Oncology 23.3 (2003): 693-696.
Chicago
Uehara, E., Takeuchi, S., Tasaka, T., Matsuhashi, Y., Yang, Y., Fujita, M., Tamura, T., Nagai, M., Koeffler, H. P."Aberrant methylation in promoter-associated CpG islands of multiple genes in therapy-related leukemia". International Journal of Oncology 23, no. 3 (2003): 693-696. https://doi.org/10.3892/ijo.23.3.693