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Enhanced cytotoxicity and nuclear accumulation of doxorubicin-loaded nanospheres in human breast cancer MCF7 cells expressing MRP1

  • Authors:
    • Nasséra Aouali
    • Hamid Morjani
    • Aurélie Trussardi
    • Emilienne Soma
    • Bruno Giroux
    • Michel Manfait

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  • Published online on: October 1, 2003     https://doi.org/10.3892/ijo.23.4.1195
  • Pages: 1195-1201
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Abstract

Previous studies have demonstrated that doxorubicin (DOX) encapsulated in polyisohexylcyano-acrylate nanospheres (NS-DOX) circumvented the resistance of breast cancer cells overexpressing P-glycoprotein (Pgp). Another protein is involved in multidrug resistance phenotype, the multidrug resistance associated protein (MRP1). We report that NS-DOX overcomes multidrug resistance in breast cancer cells overexpressing MRP1. Taking into account that anthracyclines are conjugated to or co-transported with glutathione by MRP1, these data suggest that probably due to ion pair formation (NS-DOX), MRP1 could not transport the anthracycline. Pgp is probably able to transport the ion pair drug complex and the mechanisms of drug resistance reversion in Pgp expressing cells need to be further elucidated.

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October 2003
Volume 23 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Aouali N, Morjani H, Trussardi A, Soma E, Giroux B and Manfait M: Enhanced cytotoxicity and nuclear accumulation of doxorubicin-loaded nanospheres in human breast cancer MCF7 cells expressing MRP1. Int J Oncol 23: 1195-1201, 2003.
APA
Aouali, N., Morjani, H., Trussardi, A., Soma, E., Giroux, B., & Manfait, M. (2003). Enhanced cytotoxicity and nuclear accumulation of doxorubicin-loaded nanospheres in human breast cancer MCF7 cells expressing MRP1. International Journal of Oncology, 23, 1195-1201. https://doi.org/10.3892/ijo.23.4.1195
MLA
Aouali, N., Morjani, H., Trussardi, A., Soma, E., Giroux, B., Manfait, M."Enhanced cytotoxicity and nuclear accumulation of doxorubicin-loaded nanospheres in human breast cancer MCF7 cells expressing MRP1". International Journal of Oncology 23.4 (2003): 1195-1201.
Chicago
Aouali, N., Morjani, H., Trussardi, A., Soma, E., Giroux, B., Manfait, M."Enhanced cytotoxicity and nuclear accumulation of doxorubicin-loaded nanospheres in human breast cancer MCF7 cells expressing MRP1". International Journal of Oncology 23, no. 4 (2003): 1195-1201. https://doi.org/10.3892/ijo.23.4.1195