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Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target

  • Authors:
    • Takashi Shimokawa
    • Satoshi Matsushima
    • Takuya Tsunoda
    • Hideaki Tahara
    • Yusuke Nakamura
    • Yoichi Furukawa

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  • Published online on: August 1, 2006     https://doi.org/10.3892/ijo.29.2.381
  • Pages: 381-386
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Abstract

In an attempt to isolate potential molecular targets for diagnosis, treatment and/or prevention of colorectal cancer (CRC), we have been analyzing expression profiles of clinical samples from CRC patients using genome-wide cDNA microarray. Among the genes up-regulated frequently in colorectal tumors, we here focused on TOMM34 (34 kDa-translocase of the outer mitochondrial membrane). Immunohistochemical staining revealed significant accumulation of TOMM34 protein in CRC tissues compared with their corresponding non-cancerous mucosae. Transfection of colon cancer HCT116 cells with short-interfering RNA (siRNA) specific to TOMM34 effectively suppressed its expression and drastically inhibited cell growth. These findings suggest that TOMM34 is involved in the growth of cancer cells, and may contribute to the development of novel anticancer drugs and/or diagnosis for CRC.

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Journal Cover

August 2006
Volume 29 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Shimokawa T, Matsushima S, Tsunoda T, Tahara H, Nakamura Y and Furukawa Y: Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target. Int J Oncol 29: 381-386, 2006.
APA
Shimokawa, T., Matsushima, S., Tsunoda, T., Tahara, H., Nakamura, Y., & Furukawa, Y. (2006). Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target. International Journal of Oncology, 29, 381-386. https://doi.org/10.3892/ijo.29.2.381
MLA
Shimokawa, T., Matsushima, S., Tsunoda, T., Tahara, H., Nakamura, Y., Furukawa, Y."Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target". International Journal of Oncology 29.2 (2006): 381-386.
Chicago
Shimokawa, T., Matsushima, S., Tsunoda, T., Tahara, H., Nakamura, Y., Furukawa, Y."Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target". International Journal of Oncology 29, no. 2 (2006): 381-386. https://doi.org/10.3892/ijo.29.2.381