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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1993 Volume 3 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September 1993 Volume 3 Issue 3

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Article

INHIBITORY EFFECTS OF ALPRAZOLAM ON THE ENHANCEMENT OF LUNG METASTASES INDUCED BY OPERATIVE STRESS IN RATS

  • Authors:
    • M FREIREGARABAL
    • MJ NUNEZIGLESIAS
    • JL BALBOA
    • JC FERNANDEZRIAL
    • L GARCIAVALLEJO
    • E GONZALEZPATINO
    • M REYMENDEZ

  • View Affiliations / Copyright

    Affiliations: Affliations not specified
  • Pages: 513-517
    |
    Published online on: September 1, 1993
       https://doi.org/10.3892/ijo.3.3.513
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Abstract

Experiments were performed in order to evaluate the effects of alprazolam (I mg/kg s.c.), a central benzodiazepine agonist anxiolytic, on the development of lung metastases in rats subjected to laparotomy and injected (i.v.) with 10(4) Walker 256 (W-256) carcinosarcoma cells. The number of metastatic nodules on the surface of the lungs, as well as the percentage-area of metastases in the frontal section through pulmonary hilus were increased in rats subjected to sham-surgery or laparotomy. Treatment with alprazolam partially reversed those adverse effects of surgery, but the difference was clearer when it was administered before surgery was performed. Survival periods were also assessed and alprazolam was found to decrease the lethality of rats exposed to surgery. Pretreatment with Ro 15-1788, a central benzodiazepine antagonist, suppressed the inhibitory effects of alprazolam on tumor growth.

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Copy and paste a formatted citation
Spandidos Publications style
FREIREGARABAL M, NUNEZIGLESIAS M, BALBOA J, FERNANDEZRIAL J, GARCIAVALLEJO L, GONZALEZPATINO E and REYMENDEZ M: INHIBITORY EFFECTS OF ALPRAZOLAM ON THE ENHANCEMENT OF LUNG METASTASES INDUCED BY OPERATIVE STRESS IN RATS. Int J Oncol 3: 513-517, 1993.
APA
FREIREGARABAL, M., NUNEZIGLESIAS, M., BALBOA, J., FERNANDEZRIAL, J., GARCIAVALLEJO, L., GONZALEZPATINO, E., & REYMENDEZ, M. (1993). INHIBITORY EFFECTS OF ALPRAZOLAM ON THE ENHANCEMENT OF LUNG METASTASES INDUCED BY OPERATIVE STRESS IN RATS. International Journal of Oncology, 3, 513-517. https://doi.org/10.3892/ijo.3.3.513
MLA
FREIREGARABAL, M., NUNEZIGLESIAS, M., BALBOA, J., FERNANDEZRIAL, J., GARCIAVALLEJO, L., GONZALEZPATINO, E., REYMENDEZ, M."INHIBITORY EFFECTS OF ALPRAZOLAM ON THE ENHANCEMENT OF LUNG METASTASES INDUCED BY OPERATIVE STRESS IN RATS". International Journal of Oncology 3.3 (1993): 513-517.
Chicago
FREIREGARABAL, M., NUNEZIGLESIAS, M., BALBOA, J., FERNANDEZRIAL, J., GARCIAVALLEJO, L., GONZALEZPATINO, E., REYMENDEZ, M."INHIBITORY EFFECTS OF ALPRAZOLAM ON THE ENHANCEMENT OF LUNG METASTASES INDUCED BY OPERATIVE STRESS IN RATS". International Journal of Oncology 3, no. 3 (1993): 513-517. https://doi.org/10.3892/ijo.3.3.513
Copy and paste a formatted citation
x
Spandidos Publications style
FREIREGARABAL M, NUNEZIGLESIAS M, BALBOA J, FERNANDEZRIAL J, GARCIAVALLEJO L, GONZALEZPATINO E and REYMENDEZ M: INHIBITORY EFFECTS OF ALPRAZOLAM ON THE ENHANCEMENT OF LUNG METASTASES INDUCED BY OPERATIVE STRESS IN RATS. Int J Oncol 3: 513-517, 1993.
APA
FREIREGARABAL, M., NUNEZIGLESIAS, M., BALBOA, J., FERNANDEZRIAL, J., GARCIAVALLEJO, L., GONZALEZPATINO, E., & REYMENDEZ, M. (1993). INHIBITORY EFFECTS OF ALPRAZOLAM ON THE ENHANCEMENT OF LUNG METASTASES INDUCED BY OPERATIVE STRESS IN RATS. International Journal of Oncology, 3, 513-517. https://doi.org/10.3892/ijo.3.3.513
MLA
FREIREGARABAL, M., NUNEZIGLESIAS, M., BALBOA, J., FERNANDEZRIAL, J., GARCIAVALLEJO, L., GONZALEZPATINO, E., REYMENDEZ, M."INHIBITORY EFFECTS OF ALPRAZOLAM ON THE ENHANCEMENT OF LUNG METASTASES INDUCED BY OPERATIVE STRESS IN RATS". International Journal of Oncology 3.3 (1993): 513-517.
Chicago
FREIREGARABAL, M., NUNEZIGLESIAS, M., BALBOA, J., FERNANDEZRIAL, J., GARCIAVALLEJO, L., GONZALEZPATINO, E., REYMENDEZ, M."INHIBITORY EFFECTS OF ALPRAZOLAM ON THE ENHANCEMENT OF LUNG METASTASES INDUCED BY OPERATIVE STRESS IN RATS". International Journal of Oncology 3, no. 3 (1993): 513-517. https://doi.org/10.3892/ijo.3.3.513
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