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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 1993 Volume 3 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 1993 Volume 3 Issue 4

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ANALYSIS OF PROTOONCOGENES IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK (SCCHN)

  • Authors:
    • P VOLLING
    • M JUNGEHULSING
    • H STUTZER
    • V DIEHL
    • H TESCH

  • View Affiliations / Copyright

    Affiliations: UNIV COLOGNE,INST DOKUMENTAT & STAT,W-5000 COLOGNE 41,GERMANY. UNIV COLOGNE,MED 1 KLIN,W-5000 COLOGNE 41,GERMANY.
  • Pages: 671-677
    |
    Published online on: October 1, 1993
       https://doi.org/10.3892/ijo.3.4.671
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Abstract

We have analysed DNA and RNA from 40 untreated head and neck cancers for amplified and overexpressed proto-oncogenes by Southern and Northern blot hybridisation. Coamplification but no expression of the bcl-1 and the hst genes was found in 12.5% of the patients. Furthermore, amplifications of c-myc were found in 10%, of Ha-ras and c-erbB-2 in 5%. c-erbB-2 amplification was accompanied by gene expression but no overexpression. Correlating our results with clinicopathological data of the patients amplifications were only found in stage III and IV disease (p=0.0164). No correlation was found between amplification and primary tumour site, histopathological differentiation of the tumours, response to induction chemotherapy, or survival. Our results indicate that oncogene amplification in advanced SCCHN reflects more the general genomic instability of advanced tumours than be a reason for tumour growth.

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Copy and paste a formatted citation
Spandidos Publications style
VOLLING P, JUNGEHULSING M, STUTZER H, DIEHL V and TESCH H: ANALYSIS OF PROTOONCOGENES IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK (SCCHN). Int J Oncol 3: 671-677, 1993.
APA
VOLLING, P., JUNGEHULSING, M., STUTZER, H., DIEHL, V., & TESCH, H. (1993). ANALYSIS OF PROTOONCOGENES IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK (SCCHN). International Journal of Oncology, 3, 671-677. https://doi.org/10.3892/ijo.3.4.671
MLA
VOLLING, P., JUNGEHULSING, M., STUTZER, H., DIEHL, V., TESCH, H."ANALYSIS OF PROTOONCOGENES IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK (SCCHN)". International Journal of Oncology 3.4 (1993): 671-677.
Chicago
VOLLING, P., JUNGEHULSING, M., STUTZER, H., DIEHL, V., TESCH, H."ANALYSIS OF PROTOONCOGENES IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK (SCCHN)". International Journal of Oncology 3, no. 4 (1993): 671-677. https://doi.org/10.3892/ijo.3.4.671
Copy and paste a formatted citation
x
Spandidos Publications style
VOLLING P, JUNGEHULSING M, STUTZER H, DIEHL V and TESCH H: ANALYSIS OF PROTOONCOGENES IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK (SCCHN). Int J Oncol 3: 671-677, 1993.
APA
VOLLING, P., JUNGEHULSING, M., STUTZER, H., DIEHL, V., & TESCH, H. (1993). ANALYSIS OF PROTOONCOGENES IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK (SCCHN). International Journal of Oncology, 3, 671-677. https://doi.org/10.3892/ijo.3.4.671
MLA
VOLLING, P., JUNGEHULSING, M., STUTZER, H., DIEHL, V., TESCH, H."ANALYSIS OF PROTOONCOGENES IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK (SCCHN)". International Journal of Oncology 3.4 (1993): 671-677.
Chicago
VOLLING, P., JUNGEHULSING, M., STUTZER, H., DIEHL, V., TESCH, H."ANALYSIS OF PROTOONCOGENES IN SQUAMOUS-CELL CARCINOMAS OF THE HEAD AND NECK (SCCHN)". International Journal of Oncology 3, no. 4 (1993): 671-677. https://doi.org/10.3892/ijo.3.4.671
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