Kallikrein 11 expressed in human breast cancer cells releases insulin-like growth factor through degradation of IGFBP-3

  • Authors:
    • Atsumi Sano
    • Takafumi Sangai
    • Hiroyuki Maeda
    • Michio Nakamura
    • Takahiro Hasebe
    • Atsushi Ochiai
  • View Affiliations

  • Published online on: June 1, 2007     https://doi.org/10.3892/ijo.30.6.1493
  • Pages: 1493-1498
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Abstract

Expression of human kallikrein 11 (hK11), secreted as a trypsin-like serine protease, is related to the prognosis of some human cancers, but its physiological functions in the steps of cancer progression are still unknown. In order to elucidate the enzymatic function of hK11 we investigated the substrate of hK11 and expression of KLK11, the gene encoding hK11. Among 20 human cancer cell lines tested, two estrogen receptor possessing [ER(+)] breast cancers showed the highest expression of KLK11. The investigation of the hK11 substrate showed that hK11 could degrade itself and insulin-like growth factor (IGF) binding protein 3 (IGFBP-3). Expression of KLK11 was detected in both human breast cancer tissue and in non-cancerous mammary glands, and significantly higher KLK11 expression was observed in histological grade I/II than in grade III breast cancers. The above results indicate that the hK11 expressed in ER(+) breast cancer cells may play a crucial role in breast cancer progression by increasing the bioavailability of IGFs via degradation of IGFBP-3.

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June 2007
Volume 30 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Sano A, Sangai T, Maeda H, Nakamura M, Hasebe T and Ochiai A: Kallikrein 11 expressed in human breast cancer cells releases insulin-like growth factor through degradation of IGFBP-3. Int J Oncol 30: 1493-1498, 2007.
APA
Sano, A., Sangai, T., Maeda, H., Nakamura, M., Hasebe, T., & Ochiai, A. (2007). Kallikrein 11 expressed in human breast cancer cells releases insulin-like growth factor through degradation of IGFBP-3. International Journal of Oncology, 30, 1493-1498. https://doi.org/10.3892/ijo.30.6.1493
MLA
Sano, A., Sangai, T., Maeda, H., Nakamura, M., Hasebe, T., Ochiai, A."Kallikrein 11 expressed in human breast cancer cells releases insulin-like growth factor through degradation of IGFBP-3". International Journal of Oncology 30.6 (2007): 1493-1498.
Chicago
Sano, A., Sangai, T., Maeda, H., Nakamura, M., Hasebe, T., Ochiai, A."Kallikrein 11 expressed in human breast cancer cells releases insulin-like growth factor through degradation of IGFBP-3". International Journal of Oncology 30, no. 6 (2007): 1493-1498. https://doi.org/10.3892/ijo.30.6.1493