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Ciglitazone, an agonist of peroxisome proliferator-activated receptor γ, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin

  • Authors:
    • Piotr Mrówka
    • Eliza Glodkowska
    • Dominika Nowis
    • Magdalena Legat
    • Tadeusz Issat
    • Marcin Makowski
    • Angelika Szokalska
    • Sylwia Janowska
    • Tomasz Stoklosa
    • Marek Jakóbisiak
    • Jakub Golab

  • View Affiliations

  • Published online on: January 1, 2008     https://doi.org/10.3892/ijo.32.1.249
  • Pages: 249-255
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Abstract

Thiazolidinediones are ligands of PPAR-γ, a member of the nuclear receptor family. These drugs have shown promising pre-clinical activity in tumor models but clinical studies failed to confirm their beneficial effect. We have studied the in vitro antitumor effects of a combination of ciglitazone, a thiazolidinedione drug, and lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. We observed a marked synergism in several different tumor cell lines resulting from both inhibition of cell proliferation and induction of apoptosis. These results strongly suggest that combining PPAR-γ agonists with statins can produce significant antitumor effects.

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January 2008
Volume 32 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Mrówka P, Glodkowska E, Nowis D, Legat M, Issat T, Makowski M, Szokalska A, Janowska S, Stoklosa T, Jakóbisiak M, Jakóbisiak M, et al: Ciglitazone, an agonist of peroxisome proliferator-activated receptor γ, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin. Int J Oncol 32: 249-255, 2008.
APA
Mrówka, P., Glodkowska, E., Nowis, D., Legat, M., Issat, T., Makowski, M. ... Golab, J. (2008). Ciglitazone, an agonist of peroxisome proliferator-activated receptor γ, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin. International Journal of Oncology, 32, 249-255. https://doi.org/10.3892/ijo.32.1.249
MLA
Mrówka, P., Glodkowska, E., Nowis, D., Legat, M., Issat, T., Makowski, M., Szokalska, A., Janowska, S., Stoklosa, T., Jakóbisiak, M., Golab, J."Ciglitazone, an agonist of peroxisome proliferator-activated receptor γ, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin". International Journal of Oncology 32.1 (2008): 249-255.
Chicago
Mrówka, P., Glodkowska, E., Nowis, D., Legat, M., Issat, T., Makowski, M., Szokalska, A., Janowska, S., Stoklosa, T., Jakóbisiak, M., Golab, J."Ciglitazone, an agonist of peroxisome proliferator-activated receptor γ, exerts potentiated cytostatic/cytotoxic effects against tumor cells when combined with lovastatin". International Journal of Oncology 32, no. 1 (2008): 249-255. https://doi.org/10.3892/ijo.32.1.249