search button

TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) MESSENGER-RNA EXPRESSION AND GROWTH-CONTROL IN HUMAN LUNG SQUAMOUS CARCINOMA CELL-LINES

  • Authors:
    • JMS BARTLETT
    • GJ RABIASZ
    • SP LANGDON
    • EP MILLER
    • WR MILLER

  • View Affiliations

  • Published online on: February 1, 1994     https://doi.org/10.3892/ijo.4.2.475
  • Pages: 475-479
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The pattern of TGF-beta mRNA expression and response to TGF-beta isoforms has been examined in three lung squamous carcinoma cell lines (NX002, CX140 and CX143). Expression for TGF-beta1 and TGF-beta2 but not TGF-beta3 was found in all 3 lines. TGF-beta1 and TGF-beta3 (but not TGF-beta2) inhibited the growth of the NX002 cell line in culture. The effect of TGF-beta1 on growth was accompanied with changes in the cell cycle. These data indicate that the potential for autocrine regulation by TGF-beta is present in lung squamous carcinoma cells.

Related Articles

Journal Cover

February 1994
Volume 4 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
BARTLETT J, RABIASZ G, LANGDON S, MILLER E and MILLER W: TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) MESSENGER-RNA EXPRESSION AND GROWTH-CONTROL IN HUMAN LUNG SQUAMOUS CARCINOMA CELL-LINES. Int J Oncol 4: 475-479, 1994.
APA
BARTLETT, J., RABIASZ, G., LANGDON, S., MILLER, E., & MILLER, W. (1994). TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) MESSENGER-RNA EXPRESSION AND GROWTH-CONTROL IN HUMAN LUNG SQUAMOUS CARCINOMA CELL-LINES. International Journal of Oncology, 4, 475-479. https://doi.org/10.3892/ijo.4.2.475
MLA
BARTLETT, J., RABIASZ, G., LANGDON, S., MILLER, E., MILLER, W."TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) MESSENGER-RNA EXPRESSION AND GROWTH-CONTROL IN HUMAN LUNG SQUAMOUS CARCINOMA CELL-LINES". International Journal of Oncology 4.2 (1994): 475-479.
Chicago
BARTLETT, J., RABIASZ, G., LANGDON, S., MILLER, E., MILLER, W."TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) MESSENGER-RNA EXPRESSION AND GROWTH-CONTROL IN HUMAN LUNG SQUAMOUS CARCINOMA CELL-LINES". International Journal of Oncology 4, no. 2 (1994): 475-479. https://doi.org/10.3892/ijo.4.2.475